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000181590 041__ $$aEnglish
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000181590 1001_ $$aMahamat-Saleh, Yahya$$b0
000181590 245__ $$aBaseline and lifetime alcohol consumption and risk of skin cancer in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC).
000181590 260__ $$aBognor Regis$$bWiley-Liss$$c2023
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000181590 500__ $$a2023;152:348–362
000181590 520__ $$aExperimental evidence suggests that alcohol induces cutaneous carcinogenesis, yet epidemiological studies on the link between alcohol intake and skin cancer have been inconsistent. The European Prospective Investigation into Cancer and Nutrition (EPIC) is a prospective cohort initiated in 1992 in 10 European countries. Alcohol intake at baseline and average lifetime alcohol intake were assessed using validated country-specific dietary and lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated in Cox models. A total of 14 037 skin cancer cases (melanoma: n = 2457; basal-cell carcinoma (BCC): n = 8711; squamous-cell carcinoma (SCC): n = 1928; unknown: n = 941) were identified among 450 112 participants (average follow-up: 15 years). Baseline alcohol intake was positively associated with SCC (>15 vs 0.1-4.9 g/day: HR = 1.44, 95% CI = 1.17-1.77; Ptrend = .001), BCC (HR = 1.12, 95% CI = 1.01-1.23; Ptrend = .04), and melanoma risks in men (HR = 1.17, 95% CI = 0.95-1.44; Ptrend = .17), while associations were more modest in women (SCC: HR = 1.09, 95% CI = 0.90-1.30; Ptrend = .13; BCC: HR = 1.08, 95% CI = 1.00-1.17, Ptrend = .03; melanoma: HR = 0.93, 95% CI = 0.80-1.08, Ptrend = .13). Associations were similar for lifetime alcohol intake, with an attenuated linear trend. Lifetime liquor/spirit intake was positively associated with melanoma (fourth vs first quartile: HR = 1.47, 95% CI = 1.08-1.99; Ptrend = .0009) and BCC risks in men (HR = 1.17, 95% CI = 1.04-1.31; Ptrend = .14). Baseline and lifetime intakes of wine were associated with BCC risk (HR = 1.25 in men; HR = 1.11-1.12; in women). No statistically significant associations were found between beverage types and SCC risk. Intake of beer was not associated with skin cancer risk. Our study suggests positive relationships between alcohol intake and skin cancer risk, which may have important implications for the primary prevention of skin cancer.
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000181590 650_7 $$2Other$$aalcohol
000181590 650_7 $$2Other$$acohort studies
000181590 650_7 $$2Other$$acutaneous melanoma
000181590 650_7 $$2Other$$aepidemiology
000181590 650_7 $$2Other$$akeratinocyte cancers
000181590 7001_ $$aAl-Rahmoun, Marie$$b1
000181590 7001_ $$aSeveri, Gianluca$$b2
000181590 7001_ $$00000-0002-5466-7308$$aGhiasvand, Reza$$b3
000181590 7001_ $$aVeierod, Marit B$$b4
000181590 7001_ $$aCaini, Saverio$$b5
000181590 7001_ $$aPalli, Domenico$$b6
000181590 7001_ $$00000-0002-9023-8068$$aBotteri, Edoardo$$b7
000181590 7001_ $$00000-0002-8008-5096$$aSacerdote, Carlotta$$b8
000181590 7001_ $$00000-0001-8749-9737$$aRicceri, Fulvio$$b9
000181590 7001_ $$00000-0002-3608-9743$$aLukic, Marko$$b10
000181590 7001_ $$aSánchez, Maria J$$b11
000181590 7001_ $$00000-0001-5438-970X$$aPala, Valeria$$b12
000181590 7001_ $$aTumino, Rosario$$b13
000181590 7001_ $$aChiodini, Paolo$$b14
000181590 7001_ $$aAmiano, Pilar$$b15
000181590 7001_ $$aColorado-Yohar, Sandra$$b16
000181590 7001_ $$aChirlaque, María-Dolores$$b17
000181590 7001_ $$aArdanaz, Eva$$b18
000181590 7001_ $$aBonet, Catalina$$b19
000181590 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b20$$udkfz
000181590 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b21$$udkfz
000181590 7001_ $$aSchulze, Matthias B$$b22
000181590 7001_ $$aOvervad, Kim$$b23
000181590 7001_ $$aDahm, Christina C$$b24
000181590 7001_ $$aAntoniussen, Christian S$$b25
000181590 7001_ $$aTjønneland, Anne$$b26
000181590 7001_ $$00000-0002-9083-8960$$aKyrø, Cecilie$$b27
000181590 7001_ $$aBueno-de-Mesquita, Bas$$b28
000181590 7001_ $$00000-0002-3158-5289$$aManjer, Jonas$$b29
000181590 7001_ $$aJansson, Malin$$b30
000181590 7001_ $$aEsberg, Anders$$b31
000181590 7001_ $$00000-0003-1721-4083$$aMori, Nagisa$$b32
000181590 7001_ $$00000-0001-9358-7338$$aFerrari, Pietro$$b33
000181590 7001_ $$00000-0003-2237-0128$$aWeiderpass, Elisabete$$b34
000181590 7001_ $$00000-0002-5956-5693$$aBoutron-Ruault, Marie-Christine$$b35
000181590 7001_ $$00000-0002-4557-3772$$aKvaskoff, Marina$$b36
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