TY  - JOUR
AU  - Mayén, Ana-Lucia
AU  - Viallon, Vivian
AU  - Botteri, Edoardo
AU  - Proust-Lima, Cecile
AU  - Bagnardi, Vincenzo
AU  - Batista, Veronica
AU  - Cross, Amanda J
AU  - Laouali, Nasser
AU  - MacDonald, Conor J
AU  - Severi, Gianluca
AU  - Katzke, Verena
AU  - Bergmann, Manuela M
AU  - Schulze, Mattias B
AU  - Tjønneland, Anne
AU  - Eriksen, Anne Kirstine
AU  - Dahm, Christina C
AU  - Antoniussen, Christian S
AU  - Jakszyn, Paula
AU  - Sánchez, Maria-Jose
AU  - Amiano, Pilar
AU  - Colorado-Yohar, Sandra M
AU  - Ardanaz, Eva
AU  - Travis, Ruth
AU  - Palli, Domenico
AU  - Sabina, Sieri
AU  - Tumino, Rosario
AU  - Ricceri, Fulvio
AU  - Panico, Salvatore
AU  - Bueno-de-Mesquita, Bas
AU  - Derksen, Jeroen W G
AU  - Sonestedt, Emily
AU  - Winkvist, Anna
AU  - Harlid, Sophia
AU  - Braaten, Tonje
AU  - Gram, Inger Torhild
AU  - Lukic, Marko
AU  - Jenab, Mazda
AU  - Riboli, Elio
AU  - Freisling, Heinz
AU  - Weiderpass, Elisabete
AU  - Gunter, Marc J
AU  - Ferrari, Pietro
TI  - A longitudinal evaluation of alcohol intake throughout adulthood and colorectal cancer risk.
JO  - European journal of epidemiology
VL  - 37
IS  - 9
SN  - 0393-2990
CY  - Dordrecht [u.a.]
PB  - Springer Science + Business Media B.V.
M1  - DKFZ-2022-02101
SP  - 915-929
PY  - 2022
N1  - 2022 Sep;37(9):915-929
AB  - Alcohol intake is an established risk factor for colorectal cancer (CRC); however, there is limited knowledge on whether changing alcohol drinking habits during adulthood modifies CRC risk.Leveraging longitudinal exposure assessments on alcohol intake at different ages, we examined the relationship between change in alcohol intake and subsequent CRC risk.Within the European Prospective Investigation into Cancer and Nutrition, changes in alcohol intake comparing follow-up with baseline assessments were investigated in relation to CRC risk. The analysis included 191,180, participants and 1530 incident CRC cases, with exclusion of the first three years of follow-up to minimize reverse causation. Trajectory profiles of alcohol intake, assessed at ages 20, 30, 40, 50 years, at baseline and during follow-up, were estimated using latent class mixed models and related to CRC risk, including 407,605 participants and 5,008 incident CRC cases.Mean age at baseline was 50.2 years and the follow-up assessment occurred on average 7.1 years later. Compared to stable intake, a 12 g/day increase in alcohol intake during follow-up was positively associated with CRC risk (HR = 1.15, 95
KW  - Alcohol change (Other)
KW  - Alcohol intake (Other)
KW  - Colorectal cancer (Other)
KW  - Latent class mixed models (Other)
KW  - Longitudinal exposure (Other)
KW  - Trajectory profile analysis (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36063305
DO  - DOI:10.1007/s10654-022-00900-6
UR  - https://inrepo02.dkfz.de/record/181600
ER  -