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@ARTICLE{Mayn:181600,
      author       = {A.-L. Mayén and V. Viallon and E. Botteri and C.
                      Proust-Lima and V. Bagnardi and V. Batista and A. J. Cross
                      and N. Laouali and C. J. MacDonald and G. Severi and V.
                      Katzke$^*$ and M. M. Bergmann and M. B. Schulze and A.
                      Tjønneland and A. K. Eriksen and C. C. Dahm and C. S.
                      Antoniussen and P. Jakszyn and M.-J. Sánchez and P. Amiano
                      and S. M. Colorado-Yohar and E. Ardanaz and R. Travis and D.
                      Palli and S. Sabina and R. Tumino and F. Ricceri and S.
                      Panico and B. Bueno-de-Mesquita and J. W. G. Derksen and E.
                      Sonestedt and A. Winkvist and S. Harlid and T. Braaten and
                      I. T. Gram and M. Lukic and M. Jenab and E. Riboli and H.
                      Freisling and E. Weiderpass and M. J. Gunter and P. Ferrari},
      title        = {{A} longitudinal evaluation of alcohol intake throughout
                      adulthood and colorectal cancer risk.},
      journal      = {European journal of epidemiology},
      volume       = {37},
      number       = {9},
      issn         = {0393-2990},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V.},
      reportid     = {DKFZ-2022-02101},
      pages        = {915-929},
      year         = {2022},
      note         = {2022 Sep;37(9):915-929},
      abstract     = {Alcohol intake is an established risk factor for colorectal
                      cancer (CRC); however, there is limited knowledge on whether
                      changing alcohol drinking habits during adulthood modifies
                      CRC risk.Leveraging longitudinal exposure assessments on
                      alcohol intake at different ages, we examined the
                      relationship between change in alcohol intake and subsequent
                      CRC risk.Within the European Prospective Investigation into
                      Cancer and Nutrition, changes in alcohol intake comparing
                      follow-up with baseline assessments were investigated in
                      relation to CRC risk. The analysis included 191,180,
                      participants and 1530 incident CRC cases, with exclusion of
                      the first three years of follow-up to minimize reverse
                      causation. Trajectory profiles of alcohol intake, assessed
                      at ages 20, 30, 40, 50 years, at baseline and during
                      follow-up, were estimated using latent class mixed models
                      and related to CRC risk, including 407,605 participants and
                      5,008 incident CRC cases.Mean age at baseline was 50.2 years
                      and the follow-up assessment occurred on average 7.1 years
                      later. Compared to stable intake, a 12 g/day increase in
                      alcohol intake during follow-up was positively associated
                      with CRC risk (HR = 1.15, $95\%CI$ 1.04, 1.25), while a 12
                      g/day reduction was inversely associated with CRC risk (HR =
                      0.86, $95\%CI$ 0.78, 0.95). Trajectory analysis showed that
                      compared to low alcohol intake, men who increased their
                      alcohol intake from early- to mid- and late-adulthood by up
                      to 30 g/day on average had significantly increased CRC risk
                      (HR = 1.24; $95\%CI$ 1.08, 1.42), while no associations were
                      observed in women. Results were consistent by anatomical
                      subsite.Increasing alcohol intake during mid-to-late
                      adulthood raised CRC risk, while reduction lowered risk.},
      keywords     = {Alcohol change (Other) / Alcohol intake (Other) /
                      Colorectal cancer (Other) / Latent class mixed models
                      (Other) / Longitudinal exposure (Other) / Trajectory profile
                      analysis (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36063305},
      doi          = {10.1007/s10654-022-00900-6},
      url          = {https://inrepo02.dkfz.de/record/181600},
}