%0 Journal Article
%A Li, Xiangwei
%A Delerue, Thomas
%A Schöttker, Ben
%A Holleczek, Bernd
%A Grill, Eva
%A Peters, Annette
%A Waldenberger, Melanie
%A Thorand, Barbara
%A Brenner, Hermann
%T Derivation and validation of an epigenetic frailty risk score in population-based cohorts of older adults.
%J Nature Communications
%V 13
%N 1
%@ 2041-1723
%C [London]
%I Nature Publishing Group UK
%M DKFZ-2022-02111
%P 5269
%D 2022
%Z #EA:C070#LA:C070#LA:C120#
%X DNA methylation (DNAm) patterns in peripheral blood have been shown to be associated with aging related health outcomes. We perform an epigenome-wide screening to identify CpGs related to frailty, defined by a frailty index (FI), in a large population-based cohort of older adults from Germany, the ESTHER study. Sixty-five CpGs are identified as frailty related methylation loci. Using LASSO regression, 20 CpGs are selected to derive a DNAm based algorithm for predicting frailty, the epigenetic frailty risk score (eFRS). The eFRS exhibits strong associations with frailty at baseline and after up to five-years of follow-up independently of established frailty risk factors. These associations are confirmed in another independent population-based cohort study, the KORA-Age study, conducted in older adults. In conclusion, we identify 65 CpGs as frailty-related loci, of which 20 CpGs are used to calculate the eFRS with predictive performance for frailty over long-term follow-up.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36071044
%R 10.1038/s41467-022-32893-x
%U https://inrepo02.dkfz.de/record/181611