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100 1 _ |a Li, Xiangwei
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245 _ _ |a Derivation and validation of an epigenetic frailty risk score in population-based cohorts of older adults.
260 _ _ |a [London]
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520 _ _ |a DNA methylation (DNAm) patterns in peripheral blood have been shown to be associated with aging related health outcomes. We perform an epigenome-wide screening to identify CpGs related to frailty, defined by a frailty index (FI), in a large population-based cohort of older adults from Germany, the ESTHER study. Sixty-five CpGs are identified as frailty related methylation loci. Using LASSO regression, 20 CpGs are selected to derive a DNAm based algorithm for predicting frailty, the epigenetic frailty risk score (eFRS). The eFRS exhibits strong associations with frailty at baseline and after up to five-years of follow-up independently of established frailty risk factors. These associations are confirmed in another independent population-based cohort study, the KORA-Age study, conducted in older adults. In conclusion, we identify 65 CpGs as frailty-related loci, of which 20 CpGs are used to calculate the eFRS with predictive performance for frailty over long-term follow-up.
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700 1 _ |a Delerue, Thomas
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700 1 _ |a Schöttker, Ben
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700 1 _ |a Holleczek, Bernd
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700 1 _ |a Grill, Eva
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700 1 _ |a Peters, Annette
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700 1 _ |a Waldenberger, Melanie
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700 1 _ |a Thorand, Barbara
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700 1 _ |a Brenner, Hermann
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773 _ _ |a 10.1038/s41467-022-32893-x
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