%0 Journal Article
%A Fiorito, Giovanni
%A Pedron, Sara
%A Ochoa-Rosales, Carolina
%A McCrory, Cathal
%A Polidoro, Silvia
%A Zhang, Yan
%A Dugué, Pierre-Antoine
%A Ratliff, Scott
%A Zhao, Wei N
%A McKay, Gareth J
%A Costa, Giuseppe
%A Solinas, Maria Giuliana
%A Harris, Kathleen Mullan
%A Tumino, Rosario
%A Grioni, Sara
%A Ricceri, Fulvio
%A Panico, Salvatore
%A Brenner, Hermann
%A Schwettmann, Lars
%A Waldenberger, Melanie
%A Matias-Garcia, Pamela R
%A Peters, Annette
%A Hodge, Allison
%A Giles, Graham G
%A Schmitz, Lauren L
%A Levine, Morgan
%A Smith, Jennifer A
%A Liu, Yongmei
%A Kee, Frank
%A Young, Ian S
%A McGuinness, Bernadette
%A McKnight, Amy Jayne
%A van Meurs, Joyce
%A Voortman, Trudy
%A Kenny, Rose A
%A Vineis, Paolo
%A Carmeli, Cristian
%T The Role of Epigenetic Clocks in Explaining Educational Inequalities in Mortality: A Multicohort Study and Meta-analysis.
%J The journals of gerontology / A
%V 77
%N 9
%@ 1079-5006
%C Oxford [u.a.]
%I Oxford Univ. Pr.
%M DKFZ-2022-02135
%P 1750 - 1759
%D 2022
%X Educational inequalities in all-cause mortality have been observed for decades. However, the underlying biological mechanisms are not well known. We aimed to assess the role of DNA methylation changes in blood captured by epigenetic clocks in explaining these inequalities. Data were from 8 prospective population-based cohort studies, representing 13 021 participants. First, educational inequalities and their portion explained by Horvath DNAmAge, Hannum DNAmAge, DNAmPhenoAge, and DNAmGrimAge epigenetic clocks were assessed in each cohort via counterfactual-based mediation models, on both absolute (hazard difference) and relative (hazard ratio) scales, and by sex. Second, estimates from each cohort were pooled through a random effect meta-analysis model. Men with low education had excess mortality from all causes of 57 deaths per 10 000 person-years (95
%K Educational Status
%K Epigenesis, Genetic
%K Epigenomics
%K Female
%K Humans
%K Male
%K Mortality
%K Prospective Studies
%K Risk Factors
%K Socioeconomic Factors
%K Biomarkers (Other)
%K DNA methylation (Other)
%K Longevity (Other)
%K Social inequalities (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:35172329
%R 10.1093/gerona/glac041
%U https://inrepo02.dkfz.de/record/181641