TY  - JOUR
AU  - Fiorito, Giovanni
AU  - Pedron, Sara
AU  - Ochoa-Rosales, Carolina
AU  - McCrory, Cathal
AU  - Polidoro, Silvia
AU  - Zhang, Yan
AU  - Dugué, Pierre-Antoine
AU  - Ratliff, Scott
AU  - Zhao, Wei N
AU  - McKay, Gareth J
AU  - Costa, Giuseppe
AU  - Solinas, Maria Giuliana
AU  - Harris, Kathleen Mullan
AU  - Tumino, Rosario
AU  - Grioni, Sara
AU  - Ricceri, Fulvio
AU  - Panico, Salvatore
AU  - Brenner, Hermann
AU  - Schwettmann, Lars
AU  - Waldenberger, Melanie
AU  - Matias-Garcia, Pamela R
AU  - Peters, Annette
AU  - Hodge, Allison
AU  - Giles, Graham G
AU  - Schmitz, Lauren L
AU  - Levine, Morgan
AU  - Smith, Jennifer A
AU  - Liu, Yongmei
AU  - Kee, Frank
AU  - Young, Ian S
AU  - McGuinness, Bernadette
AU  - McKnight, Amy Jayne
AU  - van Meurs, Joyce
AU  - Voortman, Trudy
AU  - Kenny, Rose A
AU  - Vineis, Paolo
AU  - Carmeli, Cristian
TI  - The Role of Epigenetic Clocks in Explaining Educational Inequalities in Mortality: A Multicohort Study and Meta-analysis.
JO  - The journals of gerontology / A
VL  - 77
IS  - 9
SN  - 1079-5006
CY  - Oxford [u.a.]
PB  - Oxford Univ. Pr.
M1  - DKFZ-2022-02135
SP  - 1750 - 1759
PY  - 2022
AB  - Educational inequalities in all-cause mortality have been observed for decades. However, the underlying biological mechanisms are not well known. We aimed to assess the role of DNA methylation changes in blood captured by epigenetic clocks in explaining these inequalities. Data were from 8 prospective population-based cohort studies, representing 13 021 participants. First, educational inequalities and their portion explained by Horvath DNAmAge, Hannum DNAmAge, DNAmPhenoAge, and DNAmGrimAge epigenetic clocks were assessed in each cohort via counterfactual-based mediation models, on both absolute (hazard difference) and relative (hazard ratio) scales, and by sex. Second, estimates from each cohort were pooled through a random effect meta-analysis model. Men with low education had excess mortality from all causes of 57 deaths per 10 000 person-years (95
KW  - Educational Status
KW  - Epigenesis, Genetic
KW  - Epigenomics
KW  - Female
KW  - Humans
KW  - Male
KW  - Mortality
KW  - Prospective Studies
KW  - Risk Factors
KW  - Socioeconomic Factors
KW  - Biomarkers (Other)
KW  - DNA methylation (Other)
KW  - Longevity (Other)
KW  - Social inequalities (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:35172329
DO  - DOI:10.1093/gerona/glac041
UR  - https://inrepo02.dkfz.de/record/181641
ER  -