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@ARTICLE{Zhu:181663,
      author       = {A. Zhu$^*$ and H. Chen and J. Shen and X. Wang and Z. Li
                      and A. Zhao and X. Shi and L. Yan and Y. Zeng and C. Yuan
                      and J. S. Ji},
      title        = {{I}nteraction between plant-based dietary pattern and air
                      pollution on cognitive function: a prospective cohort
                      analysis of {C}hinese older adults},
      journal      = {The lancet / Regional Health},
      volume       = {20},
      issn         = {2666-6065},
      address      = {[Amsterdam]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2022-02147},
      pages        = {100372},
      year         = {2022},
      note         = {Missing Journal: The Lancet Regional Health - Western
                      Pacific (The Lancet Regional Health - Western Pacific) =
                      2666-6065 (import from CrossRef, Journals: inrepo02.dkfz.de)
                      / #EA:C070# / epub},
      abstract     = {Background.Air pollution is a risk factor for poor
                      cognitive function, while a plant-based dietary pattern is
                      associated with better cognitive function. We aimed to
                      explore their interaction with cognitive function among
                      older adults.Methods.We used a prospective cohort of old
                      individuals, including 6525 participants of the Chinese
                      Longitudinal Healthy Longevity Survey (CLHLS), aged 65-110
                      years and with normal cognition at baseline. Air pollution
                      measurement was derived using satellite-derived annual
                      average fine particulate matter (PM2.5) concentrations based
                      on residential locations. Plant-based diet index (PDI) was
                      calculated using survey responses to assess the dietary
                      pattern. Repeated measures of the Mini-Mental State
                      Examination (MMSE) were utilized to assess cognitive
                      function. We applied the Cox proportional hazard regression
                      to explore the associations and further stratified the
                      analysis by PDI.Findings.During a median of 5·6-year
                      follow-up, 1537 $(23·6\%)$ out of 6525 participants with
                      normal cognition at baseline developed poor cognitive
                      function (MMSE <18). Living in areas with the highest
                      quintile of cumulative PM2.5 was associated with a $46\%$
                      increase in the risk of developing poor cognitive function
                      (hazard ratio (HR): 1·46, $95\%$ confidence interval (CI):
                      1·20, 1·77), compared to those living in areas with the
                      lowest quintile. We observed a significant interaction
                      between cumulative PM2.5 and PDI (p-interaction: 0·04),
                      with the corresponding associations of cumulative PM2.5
                      being more pronounced among participants with lower PDI (HR:
                      1·68, $95\%$ CI: 1·26, 2·24) than those with higher PDI
                      (HR: 1·28, $95\%$ CI: 0·98,
                      1·68).Interpretation.Plant-based dietary pattern may
                      attenuate detrimental impacts of PM2.5 on cognitive function
                      among older adults. Adherence to the plant-based dietary
                      pattern could be used to prevent adverse neurological
                      effects caused by air pollution, especially in developing
                      regions.},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:35028630},
      doi          = {10.1016/j.lanwpc.2021.100372},
      url          = {https://inrepo02.dkfz.de/record/181663},
}