%0 Journal Article
%A Himbert, Caroline
%A Warby, Christy A
%A Gigic, Biljana
%A Ose, Jennifer
%A Lin, Tengda
%A Viskochil, Richard
%A Peoples, Anita R
%A Ashworth, Anjelica
%A Schrotz-King, Petra
%A Scaife, Courtney L
%A Cohan, Jessica N
%A Jedrzkiewicz, Jolanta
%A Schirmacher, Peter
%A Grady, William M
%A Cohen, Stacey A
%A Krane, Mukta
%A Figueiredo, Jane C
%A Toriola, Adetunji T
%A Siegel, Erin M
%A Shibata, David
%A Round, June L
%A Huang, Lyen C
%A Li, Christopher I
%A Schneider, Martin
%A Ulrich, Alexis
%A Hardikar, Sheetal
%A Ulrich, Cornelia M
%T Associations of individual and combined physical activity and body mass index groups with pro-inflammatory biomarkers among colorectal cancer patients.
%J Cancer epidemiology, biomarkers & prevention
%V 31
%N 12
%@ 1055-9965
%C Philadelphia, Pa.
%I AACR
%M DKFZ-2022-02165
%P 2148-2156
%D 2022
%Z 2022 Dec 5;31(12):2148-2156
%X Physical activity and obesity are well-established factors of colorectal cancer (CRC) risk and prognosis. Here, we investigate associations of individual and combined physical activity and BMI groups with pro-inflammatory biomarkers in CRC patients.Self-reported physical activity levels were classified as 'active' (≥8.75 MET-hrs/wk) vs. 'inactive' (<8.75 MET-hrs/wk) in n=579 stage I-IV CRC patients enrolled in the ColoCare Study. BMI [normal weight (≥18.5-<25kg/m2), overweight (≥25-<30kg/m2), and obese (≥30kg/m2)] was abstracted from medical records. Patients were classified into four combinations of physical activity levels and BMI. Biomarkers (CRP, SAA, IL-6, IL-8, and TNF-α) in pre-surgery serum samples were measured using Meso-Scale-Discovery platform. Regression models were used to compute relative percent differences in biomarker levels by physical activity and BMI groups.'Inactive' patients had non-statistically significant higher IL-6 levels compared to 'active' patients (+36
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36099423
%R 10.1158/1055-9965.EPI-22-0681
%U https://inrepo02.dkfz.de/record/181689