TY  - JOUR
AU  - Himbert, Caroline
AU  - Warby, Christy A
AU  - Gigic, Biljana
AU  - Ose, Jennifer
AU  - Lin, Tengda
AU  - Viskochil, Richard
AU  - Peoples, Anita R
AU  - Ashworth, Anjelica
AU  - Schrotz-King, Petra
AU  - Scaife, Courtney L
AU  - Cohan, Jessica N
AU  - Jedrzkiewicz, Jolanta
AU  - Schirmacher, Peter
AU  - Grady, William M
AU  - Cohen, Stacey A
AU  - Krane, Mukta
AU  - Figueiredo, Jane C
AU  - Toriola, Adetunji T
AU  - Siegel, Erin M
AU  - Shibata, David
AU  - Round, June L
AU  - Huang, Lyen C
AU  - Li, Christopher I
AU  - Schneider, Martin
AU  - Ulrich, Alexis
AU  - Hardikar, Sheetal
AU  - Ulrich, Cornelia M
TI  - Associations of individual and combined physical activity and body mass index groups with pro-inflammatory biomarkers among colorectal cancer patients.
JO  - Cancer epidemiology, biomarkers & prevention
VL  - 31
IS  - 12
SN  - 1055-9965
CY  - Philadelphia, Pa.
PB  - AACR
M1  - DKFZ-2022-02165
SP  - 2148-2156
PY  - 2022
N1  - 2022 Dec 5;31(12):2148-2156
AB  - Physical activity and obesity are well-established factors of colorectal cancer (CRC) risk and prognosis. Here, we investigate associations of individual and combined physical activity and BMI groups with pro-inflammatory biomarkers in CRC patients.Self-reported physical activity levels were classified as 'active' (≥8.75 MET-hrs/wk) vs. 'inactive' (<8.75 MET-hrs/wk) in n=579 stage I-IV CRC patients enrolled in the ColoCare Study. BMI [normal weight (≥18.5-<25kg/m2), overweight (≥25-<30kg/m2), and obese (≥30kg/m2)] was abstracted from medical records. Patients were classified into four combinations of physical activity levels and BMI. Biomarkers (CRP, SAA, IL-6, IL-8, and TNF-α) in pre-surgery serum samples were measured using Meso-Scale-Discovery platform. Regression models were used to compute relative percent differences in biomarker levels by physical activity and BMI groups.'Inactive' patients had non-statistically significant higher IL-6 levels compared to 'active' patients (+36
LB  - PUB:(DE-HGF)16
C6  - pmid:36099423
DO  - DOI:10.1158/1055-9965.EPI-22-0681
UR  - https://inrepo02.dkfz.de/record/181689
ER  -