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@ARTICLE{Himbert:181689,
      author       = {C. Himbert and C. A. Warby and B. Gigic and J. Ose and T.
                      Lin and R. Viskochil and A. R. Peoples and A. Ashworth and
                      P. Schrotz-King$^*$ and C. L. Scaife and J. N. Cohan and J.
                      Jedrzkiewicz and P. Schirmacher and W. M. Grady and S. A.
                      Cohen and M. Krane and J. C. Figueiredo and A. T. Toriola
                      and E. M. Siegel and D. Shibata and J. L. Round and L. C.
                      Huang and C. I. Li and M. Schneider and A. Ulrich and S.
                      Hardikar and C. M. Ulrich},
      title        = {{A}ssociations of individual and combined physical activity
                      and body mass index groups with pro-inflammatory biomarkers
                      among colorectal cancer patients.},
      journal      = {Cancer epidemiology, biomarkers $\&$ prevention},
      volume       = {31},
      number       = {12},
      issn         = {1055-9965},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2022-02165},
      pages        = {2148-2156},
      year         = {2022},
      note         = {2022 Dec 5;31(12):2148-2156},
      abstract     = {Physical activity and obesity are well-established factors
                      of colorectal cancer (CRC) risk and prognosis. Here, we
                      investigate associations of individual and combined physical
                      activity and BMI groups with pro-inflammatory biomarkers in
                      CRC patients.Self-reported physical activity levels were
                      classified as 'active' (≥8.75 MET-hrs/wk) vs. 'inactive'
                      (<8.75 MET-hrs/wk) in n=579 stage I-IV CRC patients enrolled
                      in the ColoCare Study. BMI [normal weight
                      (≥18.5-<25kg/m2), overweight (≥25-<30kg/m2), and obese
                      (≥30kg/m2)] was abstracted from medical records. Patients
                      were classified into four combinations of physical activity
                      levels and BMI. Biomarkers (CRP, SAA, IL-6, IL-8, and
                      TNF-α) in pre-surgery serum samples were measured using
                      Meso-Scale-Discovery platform. Regression models were used
                      to compute relative percent differences in biomarker levels
                      by physical activity and BMI groups.'Inactive' patients had
                      non-statistically significant higher IL-6 levels compared to
                      'active' patients $(+36\%,$ p=0.10). 'Obese' patients had
                      $88\%$ and $17\%$ higher CRP and TNF-α levels compared to
                      'normal weight' patients (p=0.03 and 0.02, respectively).
                      Highest CRP levels were observed among 'overweight or
                      obese/inactive' compared to 'normal weight/active' patients
                      (p=0.03).We provide evidence of associations between
                      individual and combined physical activity and BMI groups
                      with pro-inflammatory biomarkers. While BMI was identified
                      as the key driver of inflammation, biomarker levels were
                      higher among 'inactive' patients across BMI groups.This is
                      the largest study in CRC patients investigating associations
                      of energy balance components with inflammatory biomarkers.
                      Our results suggest that physical activity may reduce
                      obesity-induced inflammation in CRC patients and support the
                      design of randomized controlled trials testing this
                      hypothesis.},
      cin          = {C120},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36099423},
      doi          = {10.1158/1055-9965.EPI-22-0681},
      url          = {https://inrepo02.dkfz.de/record/181689},
}