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| 001 | 181689 | ||
| 005 | 20240229145654.0 | ||
| 024 | 7 | _ | |a 10.1158/1055-9965.EPI-22-0681 |2 doi |
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| 041 | _ | _ | |a English |
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| 100 | 1 | _ | |a Himbert, Caroline |0 0000-0003-4084-8340 |b 0 |
| 245 | _ | _ | |a Associations of individual and combined physical activity and body mass index groups with pro-inflammatory biomarkers among colorectal cancer patients. |
| 260 | _ | _ | |a Philadelphia, Pa. |c 2022 |b AACR |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1670330104_13268 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a 2022 Dec 5;31(12):2148-2156 |
| 520 | _ | _ | |a Physical activity and obesity are well-established factors of colorectal cancer (CRC) risk and prognosis. Here, we investigate associations of individual and combined physical activity and BMI groups with pro-inflammatory biomarkers in CRC patients.Self-reported physical activity levels were classified as 'active' (≥8.75 MET-hrs/wk) vs. 'inactive' (<8.75 MET-hrs/wk) in n=579 stage I-IV CRC patients enrolled in the ColoCare Study. BMI [normal weight (≥18.5-<25kg/m2), overweight (≥25-<30kg/m2), and obese (≥30kg/m2)] was abstracted from medical records. Patients were classified into four combinations of physical activity levels and BMI. Biomarkers (CRP, SAA, IL-6, IL-8, and TNF-α) in pre-surgery serum samples were measured using Meso-Scale-Discovery platform. Regression models were used to compute relative percent differences in biomarker levels by physical activity and BMI groups.'Inactive' patients had non-statistically significant higher IL-6 levels compared to 'active' patients (+36%, p=0.10). 'Obese' patients had 88% and 17% higher CRP and TNF-α levels compared to 'normal weight' patients (p=0.03 and 0.02, respectively). Highest CRP levels were observed among 'overweight or obese/inactive' compared to 'normal weight/active' patients (p=0.03).We provide evidence of associations between individual and combined physical activity and BMI groups with pro-inflammatory biomarkers. While BMI was identified as the key driver of inflammation, biomarker levels were higher among 'inactive' patients across BMI groups.This is the largest study in CRC patients investigating associations of energy balance components with inflammatory biomarkers. Our results suggest that physical activity may reduce obesity-induced inflammation in CRC patients and support the design of randomized controlled trials testing this hypothesis. |
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| 700 | 1 | _ | |a Warby, Christy A |0 0000-0003-1772-8332 |b 1 |
| 700 | 1 | _ | |a Gigic, Biljana |b 2 |
| 700 | 1 | _ | |a Ose, Jennifer |b 3 |
| 700 | 1 | _ | |a Lin, Tengda |0 0000-0001-5147-8432 |b 4 |
| 700 | 1 | _ | |a Viskochil, Richard |0 0000-0001-7167-174X |b 5 |
| 700 | 1 | _ | |a Peoples, Anita R |0 0000-0003-3645-3960 |b 6 |
| 700 | 1 | _ | |a Ashworth, Anjelica |0 0000-0002-9676-7702 |b 7 |
| 700 | 1 | _ | |a Schrotz-King, Petra |0 P:(DE-He78)01ef71f71b01a3ec3b698653fd43fe86 |b 8 |u dkfz |
| 700 | 1 | _ | |a Scaife, Courtney L |0 0000-0003-2497-4961 |b 9 |
| 700 | 1 | _ | |a Cohan, Jessica N |0 0000-0002-5461-4716 |b 10 |
| 700 | 1 | _ | |a Jedrzkiewicz, Jolanta |0 0000-0002-9408-3139 |b 11 |
| 700 | 1 | _ | |a Schirmacher, Peter |b 12 |
| 700 | 1 | _ | |a Grady, William M |0 0000-0002-0129-7809 |b 13 |
| 700 | 1 | _ | |a Cohen, Stacey A |0 0000-0002-6207-9856 |b 14 |
| 700 | 1 | _ | |a Krane, Mukta |0 0000-0003-4872-1061 |b 15 |
| 700 | 1 | _ | |a Figueiredo, Jane C |0 0000-0001-8040-3341 |b 16 |
| 700 | 1 | _ | |a Toriola, Adetunji T |0 0000-0003-1079-2606 |b 17 |
| 700 | 1 | _ | |a Siegel, Erin M |0 0000-0003-1779-2510 |b 18 |
| 700 | 1 | _ | |a Shibata, David |0 0000-0002-5670-423X |b 19 |
| 700 | 1 | _ | |a Round, June L |0 0000-0002-7158-9874 |b 20 |
| 700 | 1 | _ | |a Huang, Lyen C |0 0000-0002-8605-2631 |b 21 |
| 700 | 1 | _ | |a Li, Christopher I |0 0000-0003-1543-0743 |b 22 |
| 700 | 1 | _ | |a Schneider, Martin |b 23 |
| 700 | 1 | _ | |a Ulrich, Alexis |0 0000-0003-1469-2186 |b 24 |
| 700 | 1 | _ | |a Hardikar, Sheetal |0 0000-0003-0292-6168 |b 25 |
| 700 | 1 | _ | |a Ulrich, Cornelia M |0 0000-0001-7641-059X |b 26 |
| 773 | _ | _ | |a 10.1158/1055-9965.EPI-22-0681 |g p. EPI-22-0681 |0 PERI:(DE-600)2036781-8 |n 12 |p 2148-2156 |t Cancer epidemiology, biomarkers & prevention |v 31 |y 2022 |x 1055-9965 |
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