%0 Journal Article
%A Trares, Kira
%A Bhardwaj, Megha
%A Perna, Laura
%A Stocker, Hannah
%A Petrera, Agnese
%A Hauck, Stefanie M
%A Beyreuther, Konrad
%A Brenner, Hermann
%A Schöttker, Ben
%T Association of the inflammation-related proteome with dementia development at older age: results from a large, prospective, population-based cohort study.
%J Alzheimer's research & therapy
%V 14
%N 1
%@ 1758-9193
%C London
%I BioMed Central
%M DKFZ-2022-02168
%P 128
%D 2022
%Z #EA:C070#LA:C070#
%X Chronic inflammation is a central feature of several forms of dementia. However, few details on the associations of blood-based inflammation-related proteins with dementia incidence have been explored yet.The Olink Target 96 Inflammation panel was measured in baseline serum samples (collected 07/2000-06/2002) of 1782 older adults from a German, population-based cohort study in a case-cohort design. Logistic regression models were used to assess the associations of biomarkers with all-cause dementia, Alzheimer's disease, and vascular dementia incidence.During 17 years of follow-up, 504 participants were diagnosed with dementia, including 163 Alzheimer's disease and 195 vascular dementia cases. After correction for multiple testing, 58 out of 72 tested (80.6
%K Aged
%K Alzheimer Disease: epidemiology
%K Cohort Studies
%K Dementia, Vascular: epidemiology
%K Humans
%K Inflammation: epidemiology
%K Prospective Studies
%K Proteome
%K Transforming Growth Factor beta1
%K Vascular Endothelial Growth Factor A
%K Alzheimer’s disease (Other)
%K Biomarker (Other)
%K Cohort study (Other)
%K Dementia (Other)
%K Inflammation (Other)
%K Vascular dementia (Other)
%K Proteome (NLM Chemicals)
%K Transforming Growth Factor beta1 (NLM Chemicals)
%K Vascular Endothelial Growth Factor A (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36085081
%2 pmc:PMC9461133
%R 10.1186/s13195-022-01063-y
%U https://inrepo02.dkfz.de/record/181692