TY  - JOUR
AU  - Trares, Kira
AU  - Bhardwaj, Megha
AU  - Perna, Laura
AU  - Stocker, Hannah
AU  - Petrera, Agnese
AU  - Hauck, Stefanie M
AU  - Beyreuther, Konrad
AU  - Brenner, Hermann
AU  - Schöttker, Ben
TI  - Association of the inflammation-related proteome with dementia development at older age: results from a large, prospective, population-based cohort study.
JO  - Alzheimer's research & therapy
VL  - 14
IS  - 1
SN  - 1758-9193
CY  - London
PB  - BioMed Central
M1  - DKFZ-2022-02168
SP  - 128
PY  - 2022
N1  - #EA:C070#LA:C070#
AB  - Chronic inflammation is a central feature of several forms of dementia. However, few details on the associations of blood-based inflammation-related proteins with dementia incidence have been explored yet.The Olink Target 96 Inflammation panel was measured in baseline serum samples (collected 07/2000-06/2002) of 1782 older adults from a German, population-based cohort study in a case-cohort design. Logistic regression models were used to assess the associations of biomarkers with all-cause dementia, Alzheimer's disease, and vascular dementia incidence.During 17 years of follow-up, 504 participants were diagnosed with dementia, including 163 Alzheimer's disease and 195 vascular dementia cases. After correction for multiple testing, 58 out of 72 tested (80.6
KW  - Aged
KW  - Alzheimer Disease: epidemiology
KW  - Cohort Studies
KW  - Dementia, Vascular: epidemiology
KW  - Humans
KW  - Inflammation: epidemiology
KW  - Prospective Studies
KW  - Proteome
KW  - Transforming Growth Factor beta1
KW  - Vascular Endothelial Growth Factor A
KW  - Alzheimer’s disease (Other)
KW  - Biomarker (Other)
KW  - Cohort study (Other)
KW  - Dementia (Other)
KW  - Inflammation (Other)
KW  - Vascular dementia (Other)
KW  - Proteome (NLM Chemicals)
KW  - Transforming Growth Factor beta1 (NLM Chemicals)
KW  - Vascular Endothelial Growth Factor A (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:36085081
C2  - pmc:PMC9461133
DO  - DOI:10.1186/s13195-022-01063-y
UR  - https://inrepo02.dkfz.de/record/181692
ER  -