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@ARTICLE{Trares:181692,
      author       = {K. Trares$^*$ and M. Bhardwaj$^*$ and L. Perna and H.
                      Stocker$^*$ and A. Petrera and S. M. Hauck and K. Beyreuther
                      and H. Brenner$^*$ and B. Schöttker$^*$},
      title        = {{A}ssociation of the inflammation-related proteome with
                      dementia development at older age: results from a large,
                      prospective, population-based cohort study.},
      journal      = {Alzheimer's research $\&$ therapy},
      volume       = {14},
      number       = {1},
      issn         = {1758-9193},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DKFZ-2022-02168},
      pages        = {128},
      year         = {2022},
      note         = {#EA:C070#LA:C070#},
      abstract     = {Chronic inflammation is a central feature of several forms
                      of dementia. However, few details on the associations of
                      blood-based inflammation-related proteins with dementia
                      incidence have been explored yet.The Olink Target 96
                      Inflammation panel was measured in baseline serum samples
                      (collected 07/2000-06/2002) of 1782 older adults from a
                      German, population-based cohort study in a case-cohort
                      design. Logistic regression models were used to assess the
                      associations of biomarkers with all-cause dementia,
                      Alzheimer's disease, and vascular dementia incidence.During
                      17 years of follow-up, 504 participants were diagnosed with
                      dementia, including 163 Alzheimer's disease and 195 vascular
                      dementia cases. After correction for multiple testing, 58
                      out of 72 tested $(80.6\%)$ biomarkers were statistically
                      significantly associated with all-cause dementia, 22 with
                      Alzheimer's disease, and 33 with vascular dementia
                      incidence. We identified four biomarker clusters, among
                      which the strongest representatives, CX3CL1, EN-RAGE, LAP
                      TGF-beta-1, and VEGF-A, were significantly associated with
                      dementia endpoints independently from other
                      inflammation-related proteins. CX3CL1 (odds ratio $[95\%$
                      confidence interval] per 1 standard deviation increase: 1.41
                      [1.24-1.60]) and EN-RAGE (1.41 [1.25-1.60]) were associated
                      with all-cause dementia incidence, EN-RAGE (1.51
                      [1.25-1.83]) and LAP TGF-beta-1 (1.46 [1.21-1.76]) with
                      Alzheimer's disease incidence, and VEGF-A (1.43 [1.20-1.70])
                      with vascular dementia incidence. All named associations
                      were stronger among APOE ε4-negative subjects.With this
                      large, population-based cohort study, we show for the first
                      time that the majority of inflammation-related proteins
                      measured in blood samples are associated with total dementia
                      incidence. Future studies should concentrate not only on
                      single biomarkers but also on the complex relationships in
                      biomarker clusters.},
      keywords     = {Aged / Alzheimer Disease: epidemiology / Cohort Studies /
                      Dementia, Vascular: epidemiology / Humans / Inflammation:
                      epidemiology / Prospective Studies / Proteome / Transforming
                      Growth Factor beta1 / Vascular Endothelial Growth Factor A /
                      Alzheimer’s disease (Other) / Biomarker (Other) / Cohort
                      study (Other) / Dementia (Other) / Inflammation (Other) /
                      Vascular dementia (Other) / Proteome (NLM Chemicals) /
                      Transforming Growth Factor beta1 (NLM Chemicals) / Vascular
                      Endothelial Growth Factor A (NLM Chemicals)},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36085081},
      pmc          = {pmc:PMC9461133},
      doi          = {10.1186/s13195-022-01063-y},
      url          = {https://inrepo02.dkfz.de/record/181692},
}