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@ARTICLE{Tietze:181803,
      author       = {A. Tietze and K. Mankad and M. H. Lequin and L. Ivarsson
                      and D. Mirsky and A. Jaju and M. Kool$^*$ and K. V. Hoff and
                      B. Bison and U. Löbel},
      title        = {{I}maging {C}haracteristics of {CNS} {N}euroblastoma-
                      {FOXR}2 : {A} {R}etrospective and {M}ulti-{I}nstitutional
                      {D}escription of 25 {C}ases},
      journal      = {American journal of neuroradiology},
      volume       = {23},
      number       = {10},
      issn         = {0195-6108},
      address      = {Oak Brook, Ill.},
      publisher    = {Soc.},
      reportid     = {DKFZ-2022-02223},
      pages        = {1476-1480},
      year         = {2022},
      note         = {2022 Sep 22;43(10):1476-1480},
      abstract     = {Background and purpose: The 5th edition of the World Health
                      Organization Classification of CNS tumors defines the CNS
                      neuroblastoma FOXR2 in the group of embryonal tumors.
                      Published clinical outcomes tend to suggest a favorable
                      outcome after resection, craniospinal irradiation, and
                      chemotherapy. This multicenter study aimed to describe
                      imaging features of CNS neuroblastoma-FOXR2, which have been
                      poorly characterized thus far.Materials and methods: On the
                      basis of a previously published cohort of tumors molecularly
                      classified as CNS neuroblastoma-FOXR2, patients with
                      available imaging data were identified. The imaging features
                      on preoperative MR imaging and CT data were recorded by 8
                      experienced pediatric neuroradiologists in consensus review
                      meetings.Results: Twenty-five patients were evaluated (13
                      girls; median age, 4.5 years). The tumors were often large
                      (mean, 115 [ SD, 83] mL), showed no $(24\%)$ or limited
                      $(60\%)$ perilesional edema, demonstrated heterogeneous
                      enhancement, were often calcified and/or hemorrhagic
                      $(52\%),$ were always T2WI-hyperintense to GM, and commonly
                      had cystic and/or necrotic components $(96\%).$ The mean ADC
                      values were low (687.8 [SD 136.3] × 10-6 mm2/s). The tumors
                      were always supratentorial. Metastases were infrequent
                      $(20\%)$ and, when present, were of nodular appearance and
                      leptomeningeal.Conclusions: In our cohort, CNS neuroblastoma
                      FOXR2 tumors showed imaging features suggesting high-grade
                      malignancy and, at the same time, showed characteristics of
                      less aggressive behavior. There are important differential
                      diagnoses, but the results of this study may assist in
                      considering this diagnosis preoperatively.},
      cin          = {B062 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36137662},
      doi          = {10.3174/ajnr.A7644},
      url          = {https://inrepo02.dkfz.de/record/181803},
}