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@ARTICLE{Schmidt:181837,
      author       = {J. A. Schmidt and I. Huybrechts and K. Overvad and A. K.
                      Eriksen and A. Tjønneland and R. Kaaks$^*$ and V. Katzke
                      and M. B. Schulze and V. Pala and C. Sacerdote and R. Tumino
                      and B. Bueno-de-Mesquita and M.-J. Sánchez and J. M. Huerta
                      and A. Barricarte and P. Amiano and A. Agudo and A. Bjartell
                      and T. Stocks and E. Thysell and M. Wennberg and E.
                      Weiderpass and R. C. Travis and T. J. Key and A.
                      Perez-Cornago},
      title        = {{P}rotein and amino acid intakes in relation to prostate
                      cancer risk and mortality-{A} prospective study in the
                      {E}uropean {P}rospective {I}nvestigation into {C}ancer and
                      {N}utrition.},
      journal      = {Cancer medicine},
      volume       = {12},
      number       = {4},
      issn         = {2045-7634},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DKFZ-2022-02252},
      pages        = {4725-4738},
      year         = {2023},
      note         = {2023 Feb;12(4):4725-4738},
      abstract     = {The association between protein intake and prostate cancer
                      risk remains unclear.To prospectively investigate the
                      associations of dietary intakes of total protein, protein
                      from different dietary sources, and amino acids with
                      prostate cancer risk and mortality.In 131,425 men from the
                      European Prospective Investigation into Cancer and
                      Nutrition, protein and amino acid intakes were estimated
                      using validated dietary questionnaires.
                      Multivariable-adjusted Cox regression models were used to
                      estimate hazard ratios (HRs) and $95\%$ confidence intervals
                      (CIs).During a mean follow-up of 14.2 years, 6939 men were
                      diagnosed with prostate cancer and 914 died of the disease.
                      Dairy protein was positively associated with overall
                      prostate cancer risk in the three highest fifths compared to
                      the lowest (HRQ3 =1.14 $(95\%$ CI 1.05-1.23); HRQ 4=1.09
                      (1.01-1.18); HRQ5 =1.10 (1.02-1.19)); similar results were
                      observed for yogurt protein (HRQ3 =1.14 (1.05-1.24); HRQ4
                      =1.09 (1.01-1.18); HRQ5 =1.12 (1.04-1.21)). For egg protein
                      intake and prostate cancer mortality, no association was
                      observed by fifths, but there was suggestive evidence of a
                      positive association in the analysis per standard deviation
                      increment. There was no strong evidence of associations with
                      different tumour subtypes.Considering the weak associations
                      and many tests, the results must be interpreted with
                      caution.This study does not provide strong evidence for an
                      association of intakes of total protein, protein from
                      different dietary sources or amino acids with prostate
                      cancer risk or mortality. However, our results may suggest
                      some weak positive associations, which need to be confirmed
                      in large-scale, pooled analyses of prospective data.},
      keywords     = {dietary amino acid intakes (Other) / dietary protein
                      intakes (Other) / prostate cancer incidence (Other) /
                      prostate cancer mortality (Other) / tumour subtypes (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36148781},
      doi          = {10.1002/cam4.5289},
      url          = {https://inrepo02.dkfz.de/record/181837},
}