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@ARTICLE{Glemser:181845,
      author       = {P. A. Glemser$^*$ and L. T. Rotkopf$^*$ and C. Ziener$^*$
                      and B. Beuthien-Baumann$^*$ and V. Weru$^*$ and A.
                      Kopp-Schneider$^*$ and H.-P. Schlemmer$^*$ and A.
                      Dimitrakopoulou-Strauss$^*$ and C. Sachpekidis$^*$},
      title        = {{H}ybrid imaging with [68{G}a]{PSMA}-11 {PET}-{CT} and
                      {PET}-{MRI} in biochemically recurrent prostate cancer.},
      journal      = {Cancer imaging},
      volume       = {22},
      number       = {1},
      issn         = {1470-7330},
      address      = {London},
      reportid     = {DKFZ-2022-02260},
      pages        = {53},
      year         = {2022},
      note         = {#EA:E010#LA:E060#},
      abstract     = {To compare [68Ga]PSMA-11 PET-CT, [68Ga]PSMA-11 PET-MRI and
                      MRI in a cohort of prostate cancer (PCa) patients in
                      biochemical recurrence after initial curative
                      therapy.Fifty-three patients with biochemically recurrent
                      PCa underwent whole-body [68Ga]PSMA-11 PET-CT 1 hour
                      post-injection (p.i.) followed by [68Ga]PSMA-11 PET-MRI 2.5
                      hours p.i., including a multiparametric MRI pelvic protocol
                      examination. Imaging data analysis consisted of visual
                      (qualitative) evaluation of the PET-CT, PET-MRI and MRI
                      scans, as well as semi-quantitative and quantitative
                      analyses of the PET and MRI data, including calculation of
                      the parameters standardized uptake value (SUV) and apparent
                      diffusion coefficient (ADC) derived from the PCa lesions.
                      Association analysis was performed between imaging and
                      clinical data, including PSA level and Gleason score. The
                      results were considered significant for p-values less than
                      0.05 (p < 0.05).The hybrid imaging modalities [68Ga]PSMA-11
                      PET-CT and PET-MRI were positive in more patients than MRI
                      alone. In particular, PET-CT detected lesions suggestive of
                      PCa relapse in 34/53 $(64.2\%),$ PET-MRI in 36/53 $(67.9\%)$
                      and MRI in 23/53 patients $(43.4\%).$ While no significant
                      differences in lesion detection rate were observed between
                      PET-CT and PET-MRI, the latter was particularly efficient in
                      detection of local recurrences in the prostate bed mainly
                      due to the contribution of the MRI part of the modality.
                      Association analysis revealed a statistically significant
                      increase in the probability of a positive scan with
                      increasing PSA levels for all imaging modalities.
                      Accordingly, there was no significant association between
                      scan positivity rate and Gleason score for any imaging
                      modality. No significant correlation was observed between
                      SUV and ADC values in lymph node metastases.[68Ga]PSMA-11
                      PET-CT and PET-MRI provide equally good detection rates for
                      PCa recurrence, both outperforming stand-alone MRI.},
      keywords     = {ADC (Other) / PET-CT (Other) / PET-MRI (Other) / Prostate
                      cancer recurrence (Other) / SUV (Other) / [68Ga]PSMA-11
                      ligand (Other)},
      cin          = {E010 / C060 / E060},
      ddc          = {610},
      cid          = {I:(DE-He78)E010-20160331 / I:(DE-He78)C060-20160331 /
                      I:(DE-He78)E060-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36138437},
      doi          = {10.1186/s40644-022-00489-9},
      url          = {https://inrepo02.dkfz.de/record/181845},
}