TY  - JOUR
AU  - Bundred, James R
AU  - Michael, Sarah
AU  - Stuart, Beth
AU  - Cutress, Ramsey I
AU  - Beckmann, Kerri
AU  - Holleczek, Bernd
AU  - Dahlstrom, Jane E
AU  - Gath, Jacqui
AU  - Dodwell, David
AU  - Bundred, Nigel J
TI  - Margin status and survival outcomes after breast cancer conservation surgery: prospectively registered systematic review and meta-analysis.
JO  - The BMJ
VL  - 378
SN  - 1756-1833
CY  - London
PB  - British Medical Association
M1  - DKFZ-2022-02265
SP  - e070346
PY  - 2022
AB  - To determine if margin involvement is associated with distant recurrence and to determine the required margin to minimise both local recurrence and distant recurrence in early stage invasive breast cancer.Prospectively registered systematic review and meta-analysis of literature.Medline (PubMed), Embase, and Proquest online databases. Unpublished data were sought from study authors.Eligible studies reported on patients undergoing breast conserving surgery (for stages I-III breast cancer), allowed an estimation of outcomes in relation to margin status, and followed up patients for a minimum of 60 months. Patients with ductal carcinoma in situ only or treated with neoadjuvant chemotherapy or by mastectomy were excluded. Where applicable, margins were categorised as tumour on ink (involved), close margins (no tumour on ink but <2 mm), and negative margins (≥2 mm).68 studies from 1 January 1980 to 31 December 2021, comprising 112 140 patients with breast cancer, were included. Across all studies, 9.4
KW  - Breast: pathology
KW  - Breast Neoplasms
KW  - Female
KW  - Humans
KW  - Margins of Excision
KW  - Mastectomy
KW  - Mastectomy, Segmental
KW  - Neoplasm Recurrence, Local
LB  - PUB:(DE-HGF)16
C6  - pmid:36130770
C2  - pmc:PMC9490551
DO  - DOI:10.1136/bmj-2022-070346
UR  - https://inrepo02.dkfz.de/record/181850
ER  -