TY  - JOUR
AU  - Webb, Adam J
AU  - Harper, Emily
AU  - Rattay, Tim
AU  - Aguado-Barrera, Miguel E
AU  - Azria, David
AU  - Bourgier, Celine
AU  - Brengues, Muriel
AU  - Briers, Erik
AU  - Bultijnck, Renée
AU  - Chang-Claude, Jenny
AU  - Choudhury, Ananya
AU  - Cicchetti, Alessandro
AU  - De Ruysscher, Dirk
AU  - De Santis, Maria Carmen
AU  - Dunning, Alison M
AU  - Elliott, Rebecca M
AU  - Fachal, Laura
AU  - Gómez-Caamaño, Antonio
AU  - Gutiérrez-Enríquez, Sara
AU  - Johnson, Kerstie
AU  - Lobato-Busto, Ramón
AU  - Kerns, Sarah L
AU  - Post, Giselle
AU  - Rancati, Tiziana
AU  - Reyes, Victoria
AU  - Rosenstein, Barry S
AU  - Seibold, Petra
AU  - Seoane, Alejandro
AU  - Sosa-Fajardo, Paloma
AU  - Sperk, Elena
AU  - Taboada-Valladares, Begoña
AU  - Valdagni, Riccardo
AU  - Vega, Ana
AU  - Veldeman, Liv
AU  - Ward, Tim
AU  - West, Catharine M
AU  - Symonds, R Paul
AU  - Talbot, Christopher J
TI  - Treatment time and circadian genotype interact to influence radiotherapy side-effects. A prospective European validation study using the REQUITE cohort.
JO  - EBioMedicine
VL  - 84
SN  - 2352-3964
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2022-02266
SP  - 104269
PY  - 2022
AB  - Circadian rhythm impacts broad biological processes, including response to cancer treatment. Evidence conflicts on whether treatment time affects risk of radiotherapy side-effects, likely because of differing time analyses and target tissues. We previously showed interactive effects of time and genotypes of circadian genes on late toxicity after breast radiotherapy and aimed to validate those results in a multi-centre cohort.Clinical and genotype data from 1690 REQUITE breast cancer patients were used with erythema (acute; n=340) and breast atrophy (two years post-radiotherapy; n=514) as primary endpoints. Local datetimes per fraction were converted into solar times as predictors. Genetic chronotype markers were included in logistic regressions to identify primary endpoint predictors.Significant predictors for erythema included BMI, radiation dose and PER3 genotype (OR 1.27(95
KW  - Breast cancer (Other)
KW  - Circadian rhythm (Other)
KW  - Genetics (Other)
KW  - Radiotherapy (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36130474
C2  - pmc:PMC9486558
DO  - DOI:10.1016/j.ebiom.2022.104269
UR  - https://inrepo02.dkfz.de/record/181851
ER  -