TY  - JOUR
AU  - Saner, Yasemin Melisa
AU  - Wiesenfarth, Manuel
AU  - Weru, Vivienn
AU  - Ladyzhensky, Boris
AU  - Tschirdewahn, Stephan
AU  - Püllen, Lukas
AU  - Bonekamp, David
AU  - Reis, Henning
AU  - Krafft, Ulrich
AU  - Heß, Jochen
AU  - Kesch, Claudia
AU  - Darr, Christopher
AU  - Forsting, Michael
AU  - Wetter, Axel
AU  - Umutlu, Lale
AU  - Haubold, Johannes
AU  - Hadaschik, Boris
AU  - Radtke, Jan Philipp
TI  - Detection of Clinically Significant Prostate Cancer Using Targeted Biopsy with Four Cores Versus Target Saturation Biopsy with Nine Cores in Transperineal Prostate Fusion Biopsy: A Prospective Randomized Trial.
JO  - European urology oncology
VL  - 6
IS  - 1
SN  - 2588-9311
CY  - Amsterdam
PB  - Elsevier
M1  - DKFZ-2022-02293
SP  - 49-55
PY  - 2023
N1  - #LA:E010# / 2023 Feb;6(1):49-55
AB  - Multiparametric magnetic resonance imaging (mpMRI) and targeted biopsy (TB) facilitate accurate detection of clinically significant prostate cancer (csPC). However, it remains unclear how targeted cores should be applied for accurate diagnosis of csPC.To assess csPC detection rates for two target-directed MRI/transrectal ultrasonography (TRUS) fusion biopsy approaches, conventional TB and target saturation biopsy (TS).This was a prospective single-center study of outcomes for transperineal MRI/TRUS fusion biopsies for 170 men. Half of the men (n = 85) were randomized to conventional TB with four cores per lesion and half (n = 85) to TS with nine cores. Biopsies were performed by three experienced board-certified urologists.PC and csPC (International Society of Urological Pathology grade group ≥2) detection rates for systematic biopsy (SB), TB, and TS were analyzed using McNemar's test for intrapatient comparisons and Fisher's exact test for TS versus TB. A combination of targeted biopsy (TS or TB) and SB served as the reference.According to the reference, csPC was diagnosed for 57 men in the TS group and 36 men in the TB group. Of these, TS detected 57/57 csPC cases and TB detected 33/36 csPC cases (p = 0.058). Detection of Gleason grade group 1 disease was 10/12 cases with TS and 8/17 cases with TB (p = 0.055). In addition, TS detected 97
KW  - Detection accuracy (Other)
KW  - Fusion biopsy (Other)
KW  - Magnetic resonance imaging (Other)
KW  - Prostate cancer (Other)
KW  - Target saturation (Other)
KW  - Targeted biopsy (Other)
KW  - Transrectal ultrasound (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36175281
DO  - DOI:10.1016/j.euo.2022.08.005
UR  - https://inrepo02.dkfz.de/record/181903
ER  -