%0 Journal Article
%A Langenberg, Karin P S
%A Meister, Michael T
%A Bakhuizen, Jette J
%A Boer, Judith M
%A van Eijkelenburg, Natasha K A
%A Hulleman, Esther
%A Ilan, Uri
%A Looze, Eleonora J
%A Dierselhuis, Miranda P
%A van der Lugt, Jasper
%A Breunis, Willemijn
%A Schild, Linda G
%A Ober, Kimberley
%A van Hooff, Sander R
%A Scheijde-Vermeulen, Marijn A
%A Hiemcke-Jiwa, Laura S
%A Flucke, Uta E
%A Kranendonk, Mariette E G
%A Wesseling, Pieter
%A Sonneveld, Edwin
%A Punt, Simone
%A Boltjes, Arjan
%A van Dijk, Freerk
%A Verwiel, Eugene T P
%A Volckmann, Richard
%A Hehir-Kwa, Jayne Y
%A Kester, Lennart A
%A Koudijs, Marco M J
%A Waanders, Esme
%A Holstege, Frank C P
%A Vormoor, H Josef
%A Hoving, Eelco W
%A van Noesel, Max M
%A Pieters, Rob
%A Kool, Marcel
%A Stumpf, Miriam
%A Blattner-Johnson, Mirjam
%A Balasubramanian, Gnana P
%A Van Tilburg, Cornelis M
%A Jones, Barbara C
%A Jones, David T W
%A Witt, Olaf
%A Pfister, Stefan M
%A Jongmans, Marjolijn C J
%A Kuiper, Roland P
%A de Krijger, Ronald R
%A Wijnen, Marc H W
%A den Boer, Monique L
%A Zwaan, C Michel
%A Kemmeren, Patrick
%A Koster, Jan
%A Tops, Bastiaan B J
%A Goemans, Bianca F
%A Molenaar, Jan J
%T Implementation of paediatric precision oncology into clinical practice: The Individualized Therapies for Children with cancer program 'iTHER'.
%J European journal of cancer
%V 175
%@ 0014-2964
%C Amsterdam [u.a.]
%I Elsevier
%M DKFZ-2022-02304
%P 311 - 325
%D 2022
%X iTHER is a Dutch prospective national precision oncology program aiming to define tumour molecular profiles in children and adolescents with primary very high-risk, relapsed, or refractory paediatric tumours. Between April 2017 and April 2021, 302 samples from 253 patients were included. Comprehensive molecular profiling including low-coverage whole genome sequencing (lcWGS), whole exome sequencing (WES), RNA sequencing (RNA-seq), Affymetrix, and/or 850k methylation profiling was successfully performed for 226 samples with at least 20
%K Adolescent (Other)
%K Cancer (Other)
%K Child (Other)
%K Hereditary (Other)
%K Molecular biology (Other)
%K Molecular targeted therapy (Other)
%K Next-generation sequencing (Other)
%K Precision medicine (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36182817
%R 10.1016/j.ejca.2022.09.001
%U https://inrepo02.dkfz.de/record/181934