%0 Journal Article
%A Misove, Adela
%A Vicha, Ales
%A Broz, Petr
%A Vanova, Katerina
%A Sumerauer, David
%A Stolova, Lucie
%A Sramkova, Lucie
%A Koblizek, Miroslav
%A Zamecnik, Josef
%A Kyncl, Martin
%A Holubova, Zuzana
%A Liby, Petr
%A Taborsky, Jakub
%A Benes, Vladimir
%A Pernikova, Ivana
%A Jones, David
%A Sill, Martin
%A Stancokova, Terezia
%A Krskova, Lenka
%A Zapotocky, Michal
%T Integrated genomic analysis reveals actionable targets in pediatric spinal cord low-grade gliomas.
%J Acta Neuropathologica Communications
%V 10
%N 1
%@ 2051-5960
%C London
%I Biomed Central
%M DKFZ-2022-02326
%P 143
%D 2022
%X Gliomas are the most common central nervous tumors in children and adolescents. However, spinal cord low-grade gliomas (sLGGs) are rare, with scarce information on tumor genomics and epigenomics. To define the molecular landscape of sLGGs, we integrated clinical data, histology, and multi-level genetic and epigenetic analyses on a consecutive cohort of 26 pediatric patients. Driver molecular alteration was found in 92
%K Adolescent
%K Astrocytoma: genetics
%K Brain Neoplasms: genetics
%K Child
%K Genomics
%K Glioma: genetics
%K Glioma: pathology
%K Humans
%K Mitogen-Activated Protein Kinase Kinases
%K Proto-Oncogene Proteins B-raf: genetics
%K Spinal Cord Neoplasms: genetics
%K KIAA1549:BRAF fusion (Other)
%K Low-grade glioma (Other)
%K Methylation profiling (Other)
%K NTRK fusion (Other)
%K Spinal cord (Other)
%K Proto-Oncogene Proteins B-raf (NLM Chemicals)
%K Mitogen-Activated Protein Kinase Kinases (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36163281
%2 pmc:PMC9513869
%R 10.1186/s40478-022-01446-0
%U https://inrepo02.dkfz.de/record/181956