TY  - JOUR
AU  - Misove, Adela
AU  - Vicha, Ales
AU  - Broz, Petr
AU  - Vanova, Katerina
AU  - Sumerauer, David
AU  - Stolova, Lucie
AU  - Sramkova, Lucie
AU  - Koblizek, Miroslav
AU  - Zamecnik, Josef
AU  - Kyncl, Martin
AU  - Holubova, Zuzana
AU  - Liby, Petr
AU  - Taborsky, Jakub
AU  - Benes, Vladimir
AU  - Pernikova, Ivana
AU  - Jones, David
AU  - Sill, Martin
AU  - Stancokova, Terezia
AU  - Krskova, Lenka
AU  - Zapotocky, Michal
TI  - Integrated genomic analysis reveals actionable targets in pediatric spinal cord low-grade gliomas.
JO  - Acta Neuropathologica Communications
VL  - 10
IS  - 1
SN  - 2051-5960
CY  - London
PB  - Biomed Central
M1  - DKFZ-2022-02326
SP  - 143
PY  - 2022
AB  - Gliomas are the most common central nervous tumors in children and adolescents. However, spinal cord low-grade gliomas (sLGGs) are rare, with scarce information on tumor genomics and epigenomics. To define the molecular landscape of sLGGs, we integrated clinical data, histology, and multi-level genetic and epigenetic analyses on a consecutive cohort of 26 pediatric patients. Driver molecular alteration was found in 92
KW  - Adolescent
KW  - Astrocytoma: genetics
KW  - Brain Neoplasms: genetics
KW  - Child
KW  - Genomics
KW  - Glioma: genetics
KW  - Glioma: pathology
KW  - Humans
KW  - Mitogen-Activated Protein Kinase Kinases
KW  - Proto-Oncogene Proteins B-raf: genetics
KW  - Spinal Cord Neoplasms: genetics
KW  - KIAA1549:BRAF fusion (Other)
KW  - Low-grade glioma (Other)
KW  - Methylation profiling (Other)
KW  - NTRK fusion (Other)
KW  - Spinal cord (Other)
KW  - Proto-Oncogene Proteins B-raf (NLM Chemicals)
KW  - Mitogen-Activated Protein Kinase Kinases (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:36163281
C2  - pmc:PMC9513869
DO  - DOI:10.1186/s40478-022-01446-0
UR  - https://inrepo02.dkfz.de/record/181956
ER  -