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000181976 1001_ $$0P:(DE-HGF)0$$aRommel, Marcel G E$$b0
000181976 245__ $$aInfluenza A virus infection instructs hematopoiesis to megakaryocyte-lineage output.
000181976 260__ $$a[New York, NY]$$bElsevier$$c2022
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000181976 520__ $$aRespiratory tract infections are among the deadliest communicable diseases worldwide. Severe cases of viral lung infections are often associated with a cytokine storm and alternating platelet numbers. We report that hematopoietic stem and progenitor cells (HSPCs) sense a non-systemic influenza A virus (IAV) infection via inflammatory cytokines. Irrespective of antiviral treatment or vaccination, at a certain threshold of IAV titer in the lung, CD41-positive hematopoietic stem cells (HSCs) enter the cell cycle while endothelial protein C receptor-positive CD41-negative HSCs remain quiescent. Active CD41-positive HSCs represent the source of megakaryocytes, while their multi-lineage reconstitution potential is reduced. This emergency megakaryopoiesis is thrombopoietin independent and attenuated in IAV-infected interleukin-1 receptor-deficient mice. Newly produced platelets during IAV infection are immature and hyper-reactive. After viral clearance, HSC quiescence is re-established. Our study reveals that non-systemic viral respiratory infection has an acute impact on HSCs via inflammatory cytokines to counteract IAV-induced thrombocytopenia.
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000181976 650_7 $$2Other$$aCP: Immunology
000181976 650_7 $$2Other$$aCP: Microbiology
000181976 650_7 $$2Other$$acytokines
000181976 650_7 $$2Other$$aemergency megakaryopoiesis
000181976 650_7 $$2Other$$ahematopoietic stem cell activation
000181976 650_7 $$2Other$$ainflammation
000181976 650_7 $$2Other$$ainfluenza
000181976 650_7 $$2Other$$aplatelet activation
000181976 650_7 $$2Other$$arespiratory virus infection
000181976 650_7 $$2Other$$avaccination
000181976 7001_ $$0P:(DE-HGF)0$$aWalz, Lisa$$b1
000181976 7001_ $$0P:(DE-He78)4bad99a2fb907a4eef4ca80c714fdc7d$$aFotopoulou, Foteini$$b2
000181976 7001_ $$0P:(DE-HGF)0$$aKohlscheen, Saskia$$b3
000181976 7001_ $$0P:(DE-HGF)0$$aSchenk, Franziska$$b4
000181976 7001_ $$0P:(DE-HGF)0$$aMiskey, Csaba$$b5
000181976 7001_ $$0P:(DE-HGF)0$$aBotezatu, Lacramioara$$b6
000181976 7001_ $$0P:(DE-HGF)0$$aKrebs, Yvonne$$b7
000181976 7001_ $$0P:(DE-HGF)0$$aVoelker, Iris M$$b8
000181976 7001_ $$0P:(DE-HGF)0$$aWittwer, Kevin$$b9
000181976 7001_ $$0P:(DE-He78)457c042884c901eb0a02c18bb1d30103$$aHolland-Letz, Tim$$b10
000181976 7001_ $$0P:(DE-HGF)0$$aIvics, Zoltán$$b11
000181976 7001_ $$0P:(DE-HGF)0$$avon Messling, Veronika$$b12
000181976 7001_ $$0P:(DE-He78)ba3fae49054b6bfaaa289b05ecd936d6$$aEssers, Marieke A G$$b13
000181976 7001_ $$0P:(DE-He78)7b613cadb8c16ce178713e15b85d982c$$aMilsom, Michael D$$b14
000181976 7001_ $$0P:(DE-HGF)0$$aPfaller, Christian K$$b15
000181976 7001_ $$0P:(DE-HGF)0$$aModlich, Ute$$b16
000181976 773__ $$0PERI:(DE-600)2649101-1$$a10.1016/j.celrep.2022.111447$$gVol. 41, no. 1, p. 111447 -$$n1$$p111447$$tCell reports$$v41$$x2211-1247$$y2022
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