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| 001 | 181976 | ||
| 005 | 20240918080425.0 | ||
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| 100 | 1 | _ | |a Rommel, Marcel G E |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Influenza A virus infection instructs hematopoiesis to megakaryocyte-lineage output. |
| 260 | _ | _ | |a [New York, NY] |c 2022 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1726639438_11602 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Respiratory tract infections are among the deadliest communicable diseases worldwide. Severe cases of viral lung infections are often associated with a cytokine storm and alternating platelet numbers. We report that hematopoietic stem and progenitor cells (HSPCs) sense a non-systemic influenza A virus (IAV) infection via inflammatory cytokines. Irrespective of antiviral treatment or vaccination, at a certain threshold of IAV titer in the lung, CD41-positive hematopoietic stem cells (HSCs) enter the cell cycle while endothelial protein C receptor-positive CD41-negative HSCs remain quiescent. Active CD41-positive HSCs represent the source of megakaryocytes, while their multi-lineage reconstitution potential is reduced. This emergency megakaryopoiesis is thrombopoietin independent and attenuated in IAV-infected interleukin-1 receptor-deficient mice. Newly produced platelets during IAV infection are immature and hyper-reactive. After viral clearance, HSC quiescence is re-established. Our study reveals that non-systemic viral respiratory infection has an acute impact on HSCs via inflammatory cytokines to counteract IAV-induced thrombocytopenia. |
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| 650 | _ | 7 | |a CP: Immunology |2 Other |
| 650 | _ | 7 | |a CP: Microbiology |2 Other |
| 650 | _ | 7 | |a cytokines |2 Other |
| 650 | _ | 7 | |a emergency megakaryopoiesis |2 Other |
| 650 | _ | 7 | |a hematopoietic stem cell activation |2 Other |
| 650 | _ | 7 | |a inflammation |2 Other |
| 650 | _ | 7 | |a influenza |2 Other |
| 650 | _ | 7 | |a platelet activation |2 Other |
| 650 | _ | 7 | |a respiratory virus infection |2 Other |
| 650 | _ | 7 | |a vaccination |2 Other |
| 700 | 1 | _ | |a Walz, Lisa |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Fotopoulou, Foteini |0 P:(DE-He78)4bad99a2fb907a4eef4ca80c714fdc7d |b 2 |
| 700 | 1 | _ | |a Kohlscheen, Saskia |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Schenk, Franziska |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Miskey, Csaba |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Botezatu, Lacramioara |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Krebs, Yvonne |0 P:(DE-HGF)0 |b 7 |
| 700 | 1 | _ | |a Voelker, Iris M |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Wittwer, Kevin |0 P:(DE-HGF)0 |b 9 |
| 700 | 1 | _ | |a Holland-Letz, Tim |0 P:(DE-He78)457c042884c901eb0a02c18bb1d30103 |b 10 |
| 700 | 1 | _ | |a Ivics, Zoltán |0 P:(DE-HGF)0 |b 11 |
| 700 | 1 | _ | |a von Messling, Veronika |0 P:(DE-HGF)0 |b 12 |
| 700 | 1 | _ | |a Essers, Marieke A G |0 P:(DE-He78)ba3fae49054b6bfaaa289b05ecd936d6 |b 13 |
| 700 | 1 | _ | |a Milsom, Michael D |0 P:(DE-He78)7b613cadb8c16ce178713e15b85d982c |b 14 |
| 700 | 1 | _ | |a Pfaller, Christian K |0 P:(DE-HGF)0 |b 15 |
| 700 | 1 | _ | |a Modlich, Ute |0 P:(DE-HGF)0 |b 16 |
| 773 | _ | _ | |a 10.1016/j.celrep.2022.111447 |g Vol. 41, no. 1, p. 111447 - |0 PERI:(DE-600)2649101-1 |n 1 |p 111447 |t Cell reports |v 41 |y 2022 |x 2211-1247 |
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