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@ARTICLE{Bonadonna:181977,
      author       = {M. Bonadonna and S. Altamura and E. Tybl$^*$ and G.
                      Palais$^*$ and M. Qatato and M. Polycarpou-Schwarz and M.
                      Schneider$^*$ and C. Kalk and W. Rüdiger$^*$ and A.
                      Ertl$^*$ and N. Anstee and R. Bogeska and D. Helm and M. D.
                      Milsom and B. Galy$^*$},
      title        = {{I}ron regulatory protein ({IRP})-mediated iron homeostasis
                      is critical for neutrophil development and differentiation
                      in the bone marrow.},
      journal      = {Science advances},
      volume       = {8},
      number       = {40},
      issn         = {2375-2548},
      address      = {Washington, DC [u.a.]},
      publisher    = {Assoc.},
      reportid     = {DKFZ-2022-02339},
      pages        = {eabq4469},
      year         = {2022},
      note         = {#EA:F170#LA:F170#},
      abstract     = {Iron is mostly devoted to the hemoglobinization of
                      erythrocytes for oxygen transport. However, emerging
                      evidence points to a broader role for the metal in
                      hematopoiesis, including the formation of the immune system.
                      Iron availability in mammalian cells is controlled by
                      iron-regulatory protein 1 (IRP1) and IRP2. We report that
                      global disruption of both IRP1 and IRP2 in adult mice
                      impairs neutrophil development and differentiation in the
                      bone marrow, yielding immature neutrophils with abnormally
                      high glycolytic and autophagic activity, resulting in
                      neutropenia. IRPs promote neutrophil differentiation in a
                      cell intrinsic manner by securing cellular iron supply
                      together with transcriptional control of neutropoiesis to
                      facilitate differentiation to fully mature neutrophils.
                      Unlike neutrophils, monocyte count was not affected by IRP
                      and iron deficiency, suggesting a lineage-specific effect of
                      iron on myeloid output. This study unveils the previously
                      unrecognized importance of IRPs and iron metabolism in the
                      formation of a major branch of the innate immune system.},
      cin          = {F170 / A012 / W120},
      ddc          = {500},
      cid          = {I:(DE-He78)F170-20160331 / I:(DE-He78)A012-20160331 /
                      I:(DE-He78)W120-20160331},
      pnm          = {316 - Infektionen, Entzündung und Krebs (POF4-316)},
      pid          = {G:(DE-HGF)POF4-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36197975},
      doi          = {10.1126/sciadv.abq4469},
      url          = {https://inrepo02.dkfz.de/record/181977},
}