guest ::
| Home > Publications database > Iron regulatory protein (IRP)-mediated iron homeostasis is critical for neutrophil development and differentiation in the bone marrow. > print |
| Home > Publications database > Iron regulatory protein (IRP)-mediated iron homeostasis is critical for neutrophil development and differentiation in the bone marrow. > print |
| 001 | 181977 | ||
| 005 | 20240229145703.0 | ||
| 024 | 7 | _ | |a 10.1126/sciadv.abq4469 |2 doi |
| 024 | 7 | _ | |a pmid:36197975 |2 pmid |
| 024 | 7 | _ | |a altmetric:136836672 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2022-02339 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 500 |
| 100 | 1 | _ | |a Bonadonna, Michael |b 0 |e First author |
| 245 | _ | _ | |a Iron regulatory protein (IRP)-mediated iron homeostasis is critical for neutrophil development and differentiation in the bone marrow. |
| 260 | _ | _ | |a Washington, DC [u.a.] |c 2022 |b Assoc. |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1669037205_7316 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a #EA:F170#LA:F170# |
| 520 | _ | _ | |a Iron is mostly devoted to the hemoglobinization of erythrocytes for oxygen transport. However, emerging evidence points to a broader role for the metal in hematopoiesis, including the formation of the immune system. Iron availability in mammalian cells is controlled by iron-regulatory protein 1 (IRP1) and IRP2. We report that global disruption of both IRP1 and IRP2 in adult mice impairs neutrophil development and differentiation in the bone marrow, yielding immature neutrophils with abnormally high glycolytic and autophagic activity, resulting in neutropenia. IRPs promote neutrophil differentiation in a cell intrinsic manner by securing cellular iron supply together with transcriptional control of neutropoiesis to facilitate differentiation to fully mature neutrophils. Unlike neutrophils, monocyte count was not affected by IRP and iron deficiency, suggesting a lineage-specific effect of iron on myeloid output. This study unveils the previously unrecognized importance of IRPs and iron metabolism in the formation of a major branch of the innate immune system. |
| 536 | _ | _ | |a 316 - Infektionen, Entzündung und Krebs (POF4-316) |0 G:(DE-HGF)POF4-316 |c POF4-316 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de |
| 700 | 1 | _ | |a Altamura, Sandro |0 0000-0002-6781-1073 |b 1 |
| 700 | 1 | _ | |a Tybl, Elisabeth |0 P:(DE-He78)ea8ac056472f2c0db921980d001d08b3 |b 2 |
| 700 | 1 | _ | |a Palais, Gael |0 P:(DE-He78)e4d85ca7303cece48a706a304fc31d79 |b 3 |
| 700 | 1 | _ | |a Qatato, Maria |b 4 |
| 700 | 1 | _ | |a Polycarpou-Schwarz, Maria |b 5 |
| 700 | 1 | _ | |a Schneider, Martin |0 P:(DE-He78)791bcedb383e7bff44eaaf21584be871 |b 6 |
| 700 | 1 | _ | |a Kalk, Christina |b 7 |
| 700 | 1 | _ | |a Rüdiger, Wibke |0 P:(DE-He78)04844af8e0787bbda58a71aec778f579 |b 8 |
| 700 | 1 | _ | |a Ertl, Alina |0 P:(DE-He78)74bde30dbc1c493a07fc0e0a0f8a3354 |b 9 |
| 700 | 1 | _ | |a Anstee, Natasha |b 10 |
| 700 | 1 | _ | |a Bogeska, Ruzhica |b 11 |
| 700 | 1 | _ | |a Helm, Dominic |b 12 |
| 700 | 1 | _ | |a Milsom, Michael D |b 13 |
| 700 | 1 | _ | |a Galy, Bruno |0 P:(DE-He78)00eb6e35f6edc7e5fcb2aacc7a21f891 |b 14 |e Last author |
| 773 | _ | _ | |a 10.1126/sciadv.abq4469 |g Vol. 8, no. 40, p. eabq4469 |0 PERI:(DE-600)2810933-8 |n 40 |p eabq4469 |t Science advances |v 8 |y 2022 |x 2375-2548 |
| 909 | C | O | |p VDB |o oai:inrepo02.dkfz.de:181977 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 2 |6 P:(DE-He78)ea8ac056472f2c0db921980d001d08b3 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 3 |6 P:(DE-He78)e4d85ca7303cece48a706a304fc31d79 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 6 |6 P:(DE-He78)791bcedb383e7bff44eaaf21584be871 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 8 |6 P:(DE-He78)04844af8e0787bbda58a71aec778f579 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 9 |6 P:(DE-He78)74bde30dbc1c493a07fc0e0a0f8a3354 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 14 |6 P:(DE-He78)00eb6e35f6edc7e5fcb2aacc7a21f891 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Krebsforschung |1 G:(DE-HGF)POF4-310 |0 G:(DE-HGF)POF4-316 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Infektionen, Entzündung und Krebs |x 0 |
| 914 | 1 | _ | |y 2022 |
| 915 | _ | _ | |a Creative Commons Attribution-NonCommercial CC BY-NC (No Version) |0 LIC:(DE-HGF)CCBYNCNV |2 V:(DE-HGF) |b DOAJ |d 2021-01-30 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2021-01-30 |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2021-01-30 |
| 915 | _ | _ | |a Article Processing Charges |0 StatID:(DE-HGF)0561 |2 StatID |d 2021-01-30 |
| 915 | _ | _ | |a Fees |0 StatID:(DE-HGF)0700 |2 StatID |d 2021-01-30 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b SCI ADV : 2021 |d 2022-11-08 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2022-11-08 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2022-11-08 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0501 |2 StatID |b DOAJ Seal |d 2021-09-20T13:50:30Z |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0500 |2 StatID |b DOAJ |d 2021-09-20T13:50:30Z |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b DOAJ : Blind peer review |d 2021-09-20T13:50:30Z |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2022-11-08 |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2022-11-08 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2022-11-08 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2022-11-08 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1040 |2 StatID |b Zoological Record |d 2022-11-08 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1150 |2 StatID |b Current Contents - Physical, Chemical and Earth Sciences |d 2022-11-08 |
| 915 | _ | _ | |a IF >= 10 |0 StatID:(DE-HGF)9910 |2 StatID |b SCI ADV : 2021 |d 2022-11-08 |
| 920 | 2 | _ | |0 I:(DE-He78)F170-20160331 |k F170 |l F170 Virus-assoziierte Karzinogenese |x 0 |
| 920 | 1 | _ | |0 I:(DE-He78)F170-20160331 |k F170 |l F170 Virus-assoziierte Karzinogenese |x 0 |
| 920 | 1 | _ | |0 I:(DE-He78)A012-20160331 |k A012 |l A012 Experimentelle Hämatologie |x 1 |
| 920 | 1 | _ | |0 I:(DE-He78)W120-20160331 |k W120 |l Proteinanalyse |x 2 |
| 920 | 0 | _ | |0 I:(DE-He78)F170-20160331 |k F170 |l F170 Virus-assoziierte Karzinogenese |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)F170-20160331 |
| 980 | _ | _ | |a I:(DE-He78)A012-20160331 |
| 980 | _ | _ | |a I:(DE-He78)W120-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|