TY  - JOUR
AU  - Stoll, Sibylle
AU  - Sowah, Solomon
AU  - Fink, Matthias A
AU  - Nonnenmacher, Tobias
AU  - Grafetstätter, Mirja
AU  - Johnson, Theron
AU  - Schlett, Christopher L
AU  - von Stackelberg, Oyunbileg
AU  - Kirsten, Romy
AU  - Bamberg, Fabian
AU  - Keller, Jeffrey
AU  - Ulrich, Cornelia M
AU  - Kaaks, Rudolf
AU  - Kauczor, Hans-Ulrich
AU  - Rengier, Fabian
AU  - Kühn, Tilman
AU  - Nattenmüller, Johanna
TI  - Changes in aortic diameter induced by weight loss: The HELENA trial- whole-body MR imaging in a dietary intervention trial.
JO  - Frontiers in physiology
VL  - 13
SN  - 1664-042X
CY  - Lausanne
PB  - Frontiers Research Foundation
M1  - DKFZ-2022-02361
SP  - 976949
PY  - 2022
N1  - #EA:C020#
AB  - Obesity-related metabolic disorders such as hypertension, hyperlipidemia and chronic inflammation have been associated with aortic dilatation and resulting in aortic aneurysms in many cases. Whether weight loss may reduce the risk of aortic dilatation is not clear. In this study, the diameter of the descending thoracic aorta, infrarenal abdominal aorta and aortic bifurcation of 144 overweight or obese non-smoking adults were measured by MR-imaging, at baseline, and 12 and 50 weeks after weight loss by calorie restriction. Changes in aortic diameter, anthropometric measures and body composition and metabolic markers were evaluated using linear mixed models. The association of the aortic diameters with the aforementioned clinical parameters was analyzed using Spearman`s correlation. Weight loss was associated with a reduction in the thoracic and abdominal aortic diameters 12 weeks after weight loss (predicted relative differences for Quartile 4: 2.5
KW  - aortic aneurysm (Other)
KW  - aortic diameter (Other)
KW  - calorie restriction weight loss (Other)
KW  - magnetic resonance imaging (Other)
KW  - obesity (Other)
KW  - overweight (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36203934
C2  - pmc:PMC9531129
DO  - DOI:10.3389/fphys.2022.976949
UR  - https://inrepo02.dkfz.de/record/182019
ER  -