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@ARTICLE{Stoll:182019,
      author       = {S. Stoll and S. Sowah$^*$ and M. A. Fink and T.
                      Nonnenmacher and M. Grafetstätter$^*$ and T. Johnson$^*$
                      and C. L. Schlett and O. von Stackelberg and R. Kirsten$^*$
                      and F. Bamberg and J. Keller and C. M. Ulrich and R.
                      Kaaks$^*$ and H.-U. Kauczor and F. Rengier and T. Kühn$^*$
                      and J. Nattenmüller},
      title        = {{C}hanges in aortic diameter induced by weight loss: {T}he
                      {HELENA} trial- whole-body {MR} imaging in a dietary
                      intervention trial.},
      journal      = {Frontiers in physiology},
      volume       = {13},
      issn         = {1664-042X},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {DKFZ-2022-02361},
      pages        = {976949},
      year         = {2022},
      note         = {#EA:C020#},
      abstract     = {Obesity-related metabolic disorders such as hypertension,
                      hyperlipidemia and chronic inflammation have been associated
                      with aortic dilatation and resulting in aortic aneurysms in
                      many cases. Whether weight loss may reduce the risk of
                      aortic dilatation is not clear. In this study, the diameter
                      of the descending thoracic aorta, infrarenal abdominal aorta
                      and aortic bifurcation of 144 overweight or obese
                      non-smoking adults were measured by MR-imaging, at baseline,
                      and 12 and 50 weeks after weight loss by calorie
                      restriction. Changes in aortic diameter, anthropometric
                      measures and body composition and metabolic markers were
                      evaluated using linear mixed models. The association of the
                      aortic diameters with the aforementioned clinical parameters
                      was analyzed using Spearman`s correlation. Weight loss was
                      associated with a reduction in the thoracic and abdominal
                      aortic diameters 12 weeks after weight loss (predicted
                      relative differences for Quartile 4: $2.5\%$ ± 0.5 and
                      $-2.2\%$ ± 0.8, p < 0.031; respectively). Furthermore,
                      there was a nominal reduction in aortic diameters during the
                      50-weeks follow-up period. Aortic diameters were positively
                      associated with weight, visceral adipose tissue, glucose,
                      HbA1c and with both systolic and diastolic blood pressure.
                      Weight loss induced by calorie restriction may reduce aortic
                      diameters. Future studies are needed to investigate, whether
                      the reduction of aortic diameters via calorie restriction
                      may help to prevent aortic aneurysms.},
      keywords     = {aortic aneurysm (Other) / aortic diameter (Other) / calorie
                      restriction weight loss (Other) / magnetic resonance imaging
                      (Other) / obesity (Other) / overweight (Other)},
      cin          = {C020 / C120},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)C120-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36203934},
      pmc          = {pmc:PMC9531129},
      doi          = {10.3389/fphys.2022.976949},
      url          = {https://inrepo02.dkfz.de/record/182019},
}