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@ARTICLE{Stoll:182019,
author = {S. Stoll and S. Sowah$^*$ and M. A. Fink and T.
Nonnenmacher and M. Grafetstätter$^*$ and T. Johnson$^*$
and C. L. Schlett and O. von Stackelberg and R. Kirsten$^*$
and F. Bamberg and J. Keller and C. M. Ulrich and R.
Kaaks$^*$ and H.-U. Kauczor and F. Rengier and T. Kühn$^*$
and J. Nattenmüller},
title = {{C}hanges in aortic diameter induced by weight loss: {T}he
{HELENA} trial- whole-body {MR} imaging in a dietary
intervention trial.},
journal = {Frontiers in physiology},
volume = {13},
issn = {1664-042X},
address = {Lausanne},
publisher = {Frontiers Research Foundation},
reportid = {DKFZ-2022-02361},
pages = {976949},
year = {2022},
note = {#EA:C020#},
abstract = {Obesity-related metabolic disorders such as hypertension,
hyperlipidemia and chronic inflammation have been associated
with aortic dilatation and resulting in aortic aneurysms in
many cases. Whether weight loss may reduce the risk of
aortic dilatation is not clear. In this study, the diameter
of the descending thoracic aorta, infrarenal abdominal aorta
and aortic bifurcation of 144 overweight or obese
non-smoking adults were measured by MR-imaging, at baseline,
and 12 and 50 weeks after weight loss by calorie
restriction. Changes in aortic diameter, anthropometric
measures and body composition and metabolic markers were
evaluated using linear mixed models. The association of the
aortic diameters with the aforementioned clinical parameters
was analyzed using Spearman`s correlation. Weight loss was
associated with a reduction in the thoracic and abdominal
aortic diameters 12 weeks after weight loss (predicted
relative differences for Quartile 4: $2.5\%$ ± 0.5 and
$-2.2\%$ ± 0.8, p < 0.031; respectively). Furthermore,
there was a nominal reduction in aortic diameters during the
50-weeks follow-up period. Aortic diameters were positively
associated with weight, visceral adipose tissue, glucose,
HbA1c and with both systolic and diastolic blood pressure.
Weight loss induced by calorie restriction may reduce aortic
diameters. Future studies are needed to investigate, whether
the reduction of aortic diameters via calorie restriction
may help to prevent aortic aneurysms.},
keywords = {aortic aneurysm (Other) / aortic diameter (Other) / calorie
restriction weight loss (Other) / magnetic resonance imaging
(Other) / obesity (Other) / overweight (Other)},
cin = {C020 / C120},
ddc = {610},
cid = {I:(DE-He78)C020-20160331 / I:(DE-He78)C120-20160331},
pnm = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
pid = {G:(DE-HGF)POF4-313},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:36203934},
pmc = {pmc:PMC9531129},
doi = {10.3389/fphys.2022.976949},
url = {https://inrepo02.dkfz.de/record/182019},
}