%0 Journal Article
%A Zhu, Anna
%A Kuznia, Sabine
%A Boakye, Daniel
%A Schöttker, Ben
%A Brenner, Hermann
%T Vitamin D-Binding Protein, Bioavailable, and Free 25(OH)D, and Mortality: A Systematic Review and Meta-Analysis.
%J Nutrients
%V 14
%N 19
%@ 2072-6643
%C Basel
%I MDPI
%M DKFZ-2022-02428
%P 3894
%D 2022
%Z #EA:C070#LA:C070#LA:C120#
%X Observational studies reported inverse associations between serum total 25-hydroxyvitamin D (25(OH)D) concentrations and mortality. Evolving evidence indicated, however, that bioavailable or free 25(OH)D may be even better predictors of mortality. We conducted a systematic review and meta-analysis to summarize the epidemiological evidence on associations of vitamin D-binding protein (VDBP), albumin-bound, bioavailable, and free 25(OH)D, with mortality.We systematically searched PubMed and Web of Science, up to 27 May 2022. Predictors of interest included serum or plasma concentrations of VDBP, albumin-bound, bioavailable, and free 25(OH)D. Assessed health outcomes were all-cause and cause-specific mortality. We included studies reporting associations between these biomarkers and mortality outcomes. We applied random-effects models for meta-analyses to summarize results from studies assessing the same vitamin D biomarkers and mortality outcomes.We identified twelve eligible studies, including ten on VDBP, eight on bioavailable 25(OH)D, and eight on free 25(OH)D. No study reported on albumin-bound 25(OH)D and mortality. In meta-analyses, the highest levels of bioavailable and free 25(OH)D were associated with 37
%K bioavailable 25(OH)D (Other)
%K free 25(OH)D (Other)
%K meta-analysis (Other)
%K mortality (Other)
%K systematic review (Other)
%K vitamin D-binding protein (VDBP) (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36235547
%R 10.3390/nu14193894
%U https://inrepo02.dkfz.de/record/182110