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000182110 1001_ $$0P:(DE-He78)e71d98af5fac4f81eb58e74b7b3095c2$$aZhu, Anna$$b0$$eFirst author$$udkfz
000182110 245__ $$aVitamin D-Binding Protein, Bioavailable, and Free 25(OH)D, and Mortality: A Systematic Review and Meta-Analysis.
000182110 260__ $$aBasel$$bMDPI$$c2022
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000182110 520__ $$aObservational studies reported inverse associations between serum total 25-hydroxyvitamin D (25(OH)D) concentrations and mortality. Evolving evidence indicated, however, that bioavailable or free 25(OH)D may be even better predictors of mortality. We conducted a systematic review and meta-analysis to summarize the epidemiological evidence on associations of vitamin D-binding protein (VDBP), albumin-bound, bioavailable, and free 25(OH)D, with mortality.We systematically searched PubMed and Web of Science, up to 27 May 2022. Predictors of interest included serum or plasma concentrations of VDBP, albumin-bound, bioavailable, and free 25(OH)D. Assessed health outcomes were all-cause and cause-specific mortality. We included studies reporting associations between these biomarkers and mortality outcomes. We applied random-effects models for meta-analyses to summarize results from studies assessing the same vitamin D biomarkers and mortality outcomes.We identified twelve eligible studies, including ten on VDBP, eight on bioavailable 25(OH)D, and eight on free 25(OH)D. No study reported on albumin-bound 25(OH)D and mortality. In meta-analyses, the highest levels of bioavailable and free 25(OH)D were associated with 37% (hazard ratio (HR): 0.63, 95% confidence interval (CI): 0.46, 0.87), and 29% (HR: 0.71, 95% CI: 0.53, 0.97) decrease in all-cause mortality, respectively, compared with the lowest levels. These estimates were similar to those for total 25(OH)D (HR: 0.67, 95% CI: 0.56, 0.80) observed in the same studies. Higher VDBP levels were associated with lower all-cause mortality in cancer patient cohorts. However, no such association was observed in general population cohorts.Similar inverse associations of total, bioavailable, and free 25(OH)D with mortality suggest that bioavailable and free 25(OH)D do not provide incremental value in predicting mortality.
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000182110 650_7 $$2Other$$abioavailable 25(OH)D
000182110 650_7 $$2Other$$afree 25(OH)D
000182110 650_7 $$2Other$$ameta-analysis
000182110 650_7 $$2Other$$amortality
000182110 650_7 $$2Other$$asystematic review
000182110 650_7 $$2Other$$avitamin D-binding protein (VDBP)
000182110 7001_ $$0P:(DE-He78)a1d1b323625dcfa155b477a646cbda52$$aKuznia, Sabine$$b1$$udkfz
000182110 7001_ $$0P:(DE-He78)657300dfd28903ec8149ca9bf5e7968d$$aBoakye, Daniel$$b2
000182110 7001_ $$0P:(DE-He78)c67a12496b8aac150c0eef888d808d46$$aSchöttker, Ben$$b3$$udkfz
000182110 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b4$$eLast author$$udkfz
000182110 773__ $$0PERI:(DE-600)2518386-2$$a10.3390/nu14193894$$gVol. 14, no. 19, p. 3894 -$$n19$$p3894$$tNutrients$$v14$$x2072-6643$$y2022
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