TY  - JOUR
AU  - Zhu, Anna
AU  - Kuznia, Sabine
AU  - Boakye, Daniel
AU  - Schöttker, Ben
AU  - Brenner, Hermann
TI  - Vitamin D-Binding Protein, Bioavailable, and Free 25(OH)D, and Mortality: A Systematic Review and Meta-Analysis.
JO  - Nutrients
VL  - 14
IS  - 19
SN  - 2072-6643
CY  - Basel
PB  - MDPI
M1  - DKFZ-2022-02428
SP  - 3894
PY  - 2022
N1  - #EA:C070#LA:C070#LA:C120#
AB  - Observational studies reported inverse associations between serum total 25-hydroxyvitamin D (25(OH)D) concentrations and mortality. Evolving evidence indicated, however, that bioavailable or free 25(OH)D may be even better predictors of mortality. We conducted a systematic review and meta-analysis to summarize the epidemiological evidence on associations of vitamin D-binding protein (VDBP), albumin-bound, bioavailable, and free 25(OH)D, with mortality.We systematically searched PubMed and Web of Science, up to 27 May 2022. Predictors of interest included serum or plasma concentrations of VDBP, albumin-bound, bioavailable, and free 25(OH)D. Assessed health outcomes were all-cause and cause-specific mortality. We included studies reporting associations between these biomarkers and mortality outcomes. We applied random-effects models for meta-analyses to summarize results from studies assessing the same vitamin D biomarkers and mortality outcomes.We identified twelve eligible studies, including ten on VDBP, eight on bioavailable 25(OH)D, and eight on free 25(OH)D. No study reported on albumin-bound 25(OH)D and mortality. In meta-analyses, the highest levels of bioavailable and free 25(OH)D were associated with 37
KW  - bioavailable 25(OH)D (Other)
KW  - free 25(OH)D (Other)
KW  - meta-analysis (Other)
KW  - mortality (Other)
KW  - systematic review (Other)
KW  - vitamin D-binding protein (VDBP) (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36235547
DO  - DOI:10.3390/nu14193894
UR  - https://inrepo02.dkfz.de/record/182110
ER  -