guest ::
| Home > Publications database > Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition. > print |
| Home > Publications database > Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition. > print |
| 001 | 182151 | ||
| 005 | 20240229145711.0 | ||
| 024 | 7 | _ | |a 10.1186/s12916-022-02553-4 |2 doi |
| 024 | 7 | _ | |a pmid:36258205 |2 pmid |
| 024 | 7 | _ | |a altmetric:137382993 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2022-02462 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Breeur, Marie |b 0 |
| 245 | _ | _ | |a Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition. |
| 260 | _ | _ | |a Heidelberg [u.a.] |c 2022 |b Springer |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1666184163_14105 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Epidemiological studies of associations between metabolites and cancer risk have typically focused on specific cancer types separately. Here, we designed a multivariate pan-cancer analysis to identify metabolites potentially associated with multiple cancer types, while also allowing the investigation of cancer type-specific associations.We analysed targeted metabolomics data available for 5828 matched case-control pairs from cancer-specific case-control studies on breast, colorectal, endometrial, gallbladder, kidney, localized and advanced prostate cancer, and hepatocellular carcinoma nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. From pre-diagnostic blood levels of an initial set of 117 metabolites, 33 cluster representatives of strongly correlated metabolites and 17 single metabolites were derived by hierarchical clustering. The mutually adjusted associations of the resulting 50 metabolites with cancer risk were examined in penalized conditional logistic regression models adjusted for body mass index, using the data-shared lasso penalty.Out of the 50 studied metabolites, (i) six were inversely associated with the risk of most cancer types: glutamine, butyrylcarnitine, lysophosphatidylcholine a C18:2, and three clusters of phosphatidylcholines (PCs); (ii) three were positively associated with most cancer types: proline, decanoylcarnitine, and one cluster of PCs; and (iii) 10 were specifically associated with particular cancer types, including histidine that was inversely associated with colorectal cancer risk and one cluster of sphingomyelins that was inversely associated with risk of hepatocellular carcinoma and positively with endometrial cancer risk.These results could provide novel insights for the identification of pathways for cancer development, in particular those shared across different cancer types. |
| 536 | _ | _ | |a 313 - Krebsrisikofaktoren und Prävention (POF4-313) |0 G:(DE-HGF)POF4-313 |c POF4-313 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de |
| 650 | _ | 7 | |a Breast |2 Other |
| 650 | _ | 7 | |a Cancer |2 Other |
| 650 | _ | 7 | |a Colorectal |2 Other |
| 650 | _ | 7 | |a EPIC |2 Other |
| 650 | _ | 7 | |a Endometrial |2 Other |
| 650 | _ | 7 | |a Kidney |2 Other |
| 650 | _ | 7 | |a Lasso |2 Other |
| 650 | _ | 7 | |a Liver |2 Other |
| 650 | _ | 7 | |a Metabolomics |2 Other |
| 650 | _ | 7 | |a Prostate |2 Other |
| 700 | 1 | _ | |a Ferrari, Pietro |b 1 |
| 700 | 1 | _ | |a Dossus, Laure |b 2 |
| 700 | 1 | _ | |a Jenab, Mazda |b 3 |
| 700 | 1 | _ | |a Johansson, Mattias |b 4 |
| 700 | 1 | _ | |a Rinaldi, Sabina |b 5 |
| 700 | 1 | _ | |a Travis, Ruth C |b 6 |
| 700 | 1 | _ | |a His, Mathilde |b 7 |
| 700 | 1 | _ | |a Key, Tim J |b 8 |
| 700 | 1 | _ | |a Schmidt, Julie A |b 9 |
| 700 | 1 | _ | |a Overvad, Kim |b 10 |
| 700 | 1 | _ | |a Tjønneland, Anne |b 11 |
| 700 | 1 | _ | |a Kyrø, Cecilie |b 12 |
| 700 | 1 | _ | |a Rothwell, Joseph A |b 13 |
| 700 | 1 | _ | |a Laouali, Nasser |b 14 |
| 700 | 1 | _ | |a Severi, Gianluca |b 15 |
| 700 | 1 | _ | |a Kaaks, Rudolf |0 P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a |b 16 |u dkfz |
| 700 | 1 | _ | |a Katzke, Verena |0 P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4 |b 17 |u dkfz |
| 700 | 1 | _ | |a Schulze, Matthias B |b 18 |
| 700 | 1 | _ | |a Eichelmann, Fabian |b 19 |
| 700 | 1 | _ | |a Palli, Domenico |b 20 |
| 700 | 1 | _ | |a Grioni, Sara |b 21 |
| 700 | 1 | _ | |a Panico, Salvatore |b 22 |
| 700 | 1 | _ | |a Tumino, Rosario |b 23 |
| 700 | 1 | _ | |a Sacerdote, Carlotta |b 24 |
| 700 | 1 | _ | |a Bueno-de-Mesquita, Bas |b 25 |
| 700 | 1 | _ | |a Olsen, Karina Standahl |b 26 |
| 700 | 1 | _ | |a Sandanger, Torkjel Manning |b 27 |
| 700 | 1 | _ | |a Nøst, Therese Haugdahl |b 28 |
| 700 | 1 | _ | |a Quirós, J Ramón |b 29 |
| 700 | 1 | _ | |a Bonet, Catalina |b 30 |
| 700 | 1 | _ | |a Barranco, Miguel Rodríguez |b 31 |
| 700 | 1 | _ | |a Chirlaque, María-Dolores |b 32 |
| 700 | 1 | _ | |a Ardanaz, Eva |b 33 |
| 700 | 1 | _ | |a Sandsveden, Malte |b 34 |
| 700 | 1 | _ | |a Manjer, Jonas |b 35 |
| 700 | 1 | _ | |a Vidman, Linda |b 36 |
| 700 | 1 | _ | |a Rentoft, Matilda |b 37 |
| 700 | 1 | _ | |a Muller, David |b 38 |
| 700 | 1 | _ | |a Tsilidis, Kostas |b 39 |
| 700 | 1 | _ | |a Heath, Alicia K |b 40 |
| 700 | 1 | _ | |a Keun, Hector |b 41 |
| 700 | 1 | _ | |a Adamski, Jerzy |b 42 |
| 700 | 1 | _ | |a Keski-Rahkonen, Pekka |b 43 |
| 700 | 1 | _ | |a Scalbert, Augustin |b 44 |
| 700 | 1 | _ | |a Gunter, Marc J |b 45 |
| 700 | 1 | _ | |a Viallon, Vivian |b 46 |
| 773 | _ | _ | |a 10.1186/s12916-022-02553-4 |g Vol. 20, no. 1, p. 351 |0 PERI:(DE-600)2131669-7 |n 1 |p 351 |t BMC medicine |v 20 |y 2022 |x 1741-7015 |
| 909 | C | O | |o oai:inrepo02.dkfz.de:182151 |p VDB |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 16 |6 P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 17 |6 P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Krebsforschung |1 G:(DE-HGF)POF4-310 |0 G:(DE-HGF)POF4-313 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Krebsrisikofaktoren und Prävention |x 0 |
| 914 | 1 | _ | |y 2022 |
| 915 | _ | _ | |a Creative Commons Attribution CC BY (No Version) |0 LIC:(DE-HGF)CCBYNV |2 V:(DE-HGF) |b DOAJ |d 2021-01-29 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2021-01-29 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1190 |2 StatID |b Biological Abstracts |d 2021-01-29 |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2021-01-29 |
| 915 | _ | _ | |a Article Processing Charges |0 StatID:(DE-HGF)0561 |2 StatID |d 2021-01-29 |
| 915 | _ | _ | |a Fees |0 StatID:(DE-HGF)0700 |2 StatID |d 2021-01-29 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b BMC MED : 2021 |d 2022-11-25 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2022-11-25 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2022-11-25 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0501 |2 StatID |b DOAJ Seal |d 2021-02-14T16:19:46Z |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0500 |2 StatID |b DOAJ |d 2021-02-14T16:19:46Z |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b DOAJ : Open peer review |d 2021-02-14T16:19:46Z |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2022-11-25 |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2022-11-25 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2022-11-25 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2022-11-25 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2022-11-25 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1110 |2 StatID |b Current Contents - Clinical Medicine |d 2022-11-25 |
| 915 | _ | _ | |a IF >= 10 |0 StatID:(DE-HGF)9910 |2 StatID |b BMC MED : 2021 |d 2022-11-25 |
| 920 | 1 | _ | |0 I:(DE-He78)C020-20160331 |k C020 |l C020 Epidemiologie von Krebs |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)C020-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|