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@ARTICLE{Zhou:182171,
      author       = {F. Zhou and N. Aroua$^*$ and Y. Liu and C. Rohde and J.
                      Cheng and A.-K. Wirth and D. Fijalkowska$^*$ and S. Göllner
                      and M. Lotze and H. Yun and X. Yu and C. Pabst and T. Sauer
                      and T. Oellerich and H. Serve and C. Rollig and M.
                      Bornhauser and C. Thiede and C. Baldus and M. Frye$^*$ and
                      S. Raffel and J. Krijgsveld$^*$ and I. Jeremias$^*$ and R.
                      Beckmann and A. Trumpp$^*$ and C. Muller-Tidow},
      title        = {{A} dynamic r{RNA} ribomethylome drives stemness in acute
                      myeloid leukemia.},
      journal      = {Cancer discovery},
      volume       = {13},
      number       = {2},
      issn         = {2159-8274},
      address      = {Philadelphia, Pa.},
      reportid     = {DKFZ-2022-02474},
      pages        = {332-347},
      year         = {2023},
      note         = {#EA:A010#LA:A010# / 2023 Feb 6;13(2):332-347},
      abstract     = {The development and regulation of malignant self-renewal
                      remains an unresolved issue. Here, we provide biochemical,
                      genetic, and functional evidence that dynamics in ribosomal
                      RNA (rRNA) 2'-O-methylation regulate leukemia stem cell
                      (LSC) activity in vivo. A comprehensive analysis of the rRNA
                      2'-O-methylation landscape of 94 acute myeloid leukemia
                      (AML) patients revealed dynamic 2'-O-methylation
                      specifically at exterior sites of ribosomes. rRNA
                      2'-O-methylation pattern is closely associated with AML
                      development stage and LSC gene expression signature. Forced
                      expression of 2'-O-methyltransferase FBL induced an AML stem
                      cell phenotype and enabled engraftment of non-LSC leukemia
                      cells in NSG mice. Enhanced 2'-O-methylation redirected the
                      ribosome translation program towards amino acid transporter
                      mRNAs enriched in optimal codons and subsequently increased
                      intracellular amino acid levels. Methylation at the single
                      site 18S-guanosine 1447 was instrumental for LSC activity.
                      Collectively, our work demonstrates that dynamic 2'-O-Me at
                      specific sites on ribosomal RNAs shifts translational
                      preferences and controls AML-LSC self-renewal.},
      cin          = {A010 / B230 / A350 / MU01},
      ddc          = {610},
      cid          = {I:(DE-He78)A010-20160331 / I:(DE-He78)B230-20160331 /
                      I:(DE-He78)A350-20160331 / I:(DE-He78)MU01-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36259929},
      doi          = {10.1158/2159-8290.CD-22-0210},
      url          = {https://inrepo02.dkfz.de/record/182171},
}