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| 001 | 182171 | ||
| 005 | 20240229145712.0 | ||
| 024 | 7 | _ | |a 10.1158/2159-8290.CD-22-0210 |2 doi |
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| 037 | _ | _ | |a DKFZ-2022-02474 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Zhou, Fengbiao |b 0 |
| 245 | _ | _ | |a A dynamic rRNA ribomethylome drives stemness in acute myeloid leukemia. |
| 260 | _ | _ | |a Philadelphia, Pa. |c 2023 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1675694567_31406 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a #EA:A010#LA:A010# / 2023 Feb 6;13(2):332-347 |
| 520 | _ | _ | |a The development and regulation of malignant self-renewal remains an unresolved issue. Here, we provide biochemical, genetic, and functional evidence that dynamics in ribosomal RNA (rRNA) 2'-O-methylation regulate leukemia stem cell (LSC) activity in vivo. A comprehensive analysis of the rRNA 2'-O-methylation landscape of 94 acute myeloid leukemia (AML) patients revealed dynamic 2'-O-methylation specifically at exterior sites of ribosomes. rRNA 2'-O-methylation pattern is closely associated with AML development stage and LSC gene expression signature. Forced expression of 2'-O-methyltransferase FBL induced an AML stem cell phenotype and enabled engraftment of non-LSC leukemia cells in NSG mice. Enhanced 2'-O-methylation redirected the ribosome translation program towards amino acid transporter mRNAs enriched in optimal codons and subsequently increased intracellular amino acid levels. Methylation at the single site 18S-guanosine 1447 was instrumental for LSC activity. Collectively, our work demonstrates that dynamic 2'-O-Me at specific sites on ribosomal RNAs shifts translational preferences and controls AML-LSC self-renewal. |
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| 700 | 1 | _ | |a Liu, Yi |b 2 |
| 700 | 1 | _ | |a Rohde, Christian |0 0000-0001-6778-5971 |b 3 |
| 700 | 1 | _ | |a Cheng, Jingdong |0 0000-0003-4442-377X |b 4 |
| 700 | 1 | _ | |a Wirth, Anna-Katharina |0 0000-0002-0138-8583 |b 5 |
| 700 | 1 | _ | |a Fijalkowska, Daria |0 P:(DE-He78)750580c70861171188621241d0254b3d |b 6 |
| 700 | 1 | _ | |a Göllner, Stefanie |0 0000-0002-2934-1920 |b 7 |
| 700 | 1 | _ | |a Lotze, Michelle |b 8 |
| 700 | 1 | _ | |a Yun, Haiyang |0 0000-0001-8714-205X |b 9 |
| 700 | 1 | _ | |a Yu, Xiaobing |0 0000-0001-8634-4135 |b 10 |
| 700 | 1 | _ | |a Pabst, Caroline |b 11 |
| 700 | 1 | _ | |a Sauer, Tim |b 12 |
| 700 | 1 | _ | |a Oellerich, Thomas |b 13 |
| 700 | 1 | _ | |a Serve, Hubert |0 0000-0001-8472-5516 |b 14 |
| 700 | 1 | _ | |a Rollig, Christoph |0 0000-0002-3791-0548 |b 15 |
| 700 | 1 | _ | |a Bornhauser, Martin |b 16 |
| 700 | 1 | _ | |a Thiede, Christian |0 0000-0003-1241-2048 |b 17 |
| 700 | 1 | _ | |a Baldus, Claudia |0 0000-0002-0748-834X |b 18 |
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| 700 | 1 | _ | |a Raffel, Simon |b 20 |
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| 700 | 1 | _ | |a Jeremias, Irmela |0 P:(DE-He78)0dc58a3349e4e66a46410a2067e43828 |b 22 |u dkfz |
| 700 | 1 | _ | |a Beckmann, Roland |0 0000-0003-4291-3898 |b 23 |
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| 700 | 1 | _ | |a Muller-Tidow, Carsten |b 25 |
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