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@ARTICLE{Hbers:182202,
      author       = {C. Hübers$^*$ and A. A. Abdul Pari$^*$ and D.
                      Grieshober$^*$ and M. Petkov$^*$ and A. Schmidt and T.
                      Messmer$^*$ and C. M. Heyer and S. Schölch$^*$ and S.
                      Kapel$^*$ and N. Gengenbacher$^*$ and M. Singhal$^*$ and B.
                      Schieb$^*$ and C. Fricke$^*$ and R. Will$^*$ and K. Remans
                      and J. Utikal$^*$ and C. Reissfelder and M. Schlesner and K.
                      M. Hodivala-Dilke and S. Kersten and S. Goerdt and H.
                      Augustin$^*$ and M. Felcht$^*$},
      title        = {{P}rimary tumor-derived systemic n{ANGPTL}4 inhibits
                      metastasis.},
      journal      = {Journal of experimental medicine},
      volume       = {220},
      number       = {1},
      issn         = {0022-1007},
      address      = {New York, NY},
      publisher    = {Rockefeller Univ. Press},
      reportid     = {DKFZ-2022-02496},
      pages        = {e20202595},
      year         = {2023},
      note         = {#EA:A190#LA:A190# / DKFZ-ZMBH Alliance},
      abstract     = {Primary tumors and distant site metastases form a
                      bidirectionally communicating system. Yet, the molecular
                      mechanisms of this crosstalk are poorly understood. Here, we
                      identified the proteolytically cleaved fragments of
                      angiopoietin-like 4 (ANGPTL4) as contextually active
                      protumorigenic and antitumorigenic contributors in this
                      communication ecosystem. Preclinical studies in multiple
                      tumor models revealed that the C-terminal fragment
                      (cANGPTL4) promoted tumor growth and metastasis. In
                      contrast, the N-terminal fragment of ANGPTL4 (nANGPTL4)
                      inhibited metastasis and enhanced overall survival in a
                      postsurgical metastasis model by inhibiting WNT signaling
                      and reducing vascularity at the metastatic site. Tracing
                      ANGPTL4 and its fragments in tumor patients detected
                      full-length ANGPTL4 primarily in tumor tissues, whereas
                      nANGPTL4 predominated in systemic circulation and correlated
                      inversely with disease progression. The study highlights the
                      spatial context of the proteolytic cleavage-dependent pro-
                      and antitumorigenic functions of ANGPTL4 and identifies and
                      validates nANGPTL4 as a novel biomarker of tumor progression
                      and antimetastatic therapeutic agent.},
      cin          = {A190 / A430 / W111 / A370},
      ddc          = {610},
      cid          = {I:(DE-He78)A190-20160331 / I:(DE-He78)A430-20160331 /
                      I:(DE-He78)W111-20160331 / I:(DE-He78)A370-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36269299},
      doi          = {10.1084/jem.20202595},
      url          = {https://inrepo02.dkfz.de/record/182202},
}