Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes.

Berndt, Sonja I; Cox, David G; Diver, W Ryan; Molina, Thierry J; Lan, Qing; Kleinstern, Geffen; Morton, Lindsay M; Bhatti, Parveen; Chiu, Brian C H; Fraumeni, Joseph F; Roman, Eve; Glimelius, Bengt; Colditz, Graham; Cerhan, James R; Van Den Berg, Anke; Offit, Kenneth; Southey, Melissa C; Van Den Berg, David J; McKay, James; Chang, Ellen T; Purdue, Mark P; Song, Lei; Riby, Jacques; Gu, Jian; Maynadie, Marc; Foretova, Lenka; Rothman, Nathaniel; Weinstein, Stephanie; Holford, Theodore R; Lawrence, Charles; Ziv, Elad; Kaaks, Rudolph; Ye, Yuanqing; Edlund, Christopher K; Doo, Nicole Wong; Hjalgrim, Henrik; Ansell, Stephen M; Hutchinson, Amy; Chung, Charles C; Cannon-Albright, Lisa A; Vachon, Celine M; Zhang, Yawei; Wu, Xifeng; Tinker, Lesley F; Kraft, Peter; Stephens, Deborah; Brennan, Paul; Wang, Zhaoming; Melbye, Mads; Spinelli, John J; Slager, Susan L; De Vivo, Immaculata; Wang, Sophia S; Yu, Kai; Link, Brian K; Kricker, Anne; Travis, Ruth C; Weiner, George J; Tilly, Hervé; Clavel, Jacqueline; Song, Kevin W; Casabonne, Delphine; Chatterjee, Nilanjan; Kane, Eleanor; Tkachuk, Kaitlyn; North, Kari E; Anderson, Kenneth C; Camp, Nicola J; Benavente, Yolanda; Conti, David V; Haioun, Corinne; Sborov, Douglas W; Arias, Joshua; Zeleniuch-Jacquotte, Anne; Besson, Caroline; Sutherland, Heather J; Jarrett, Ruth F; Dogan, Ahmet; Giles, Graham G; Kong, Yinfei; Staines, Anthony; Onel, Kenan; Zheng, Tongzhang; Burdett, Laurie; Habermann, Thomas M; Izhar, Aalin; Boffetta, Paolo; Vijai, Joseph; Bassig, Bryan; Hofmann, Jonathan N; Salles, Gilles; Ghesquières, Hervé; Rand, Kristin A; Turner, Jenny; Jackson, Rebecca D; Thompson, Carrie A; Becker, Nikolaus; Teras, Lauren R; Montalvan, Rebecca; Smith, Alexandra; Yeager, Meredith; Skibola, Christine F; Milne, Roger L; Shanafelt, Tait D; Kolonel, Laurence N; Vineis, Paolo; Cocco, Pierluigi; Riboli, Elio; Miligi, Lucia; Curtin, Karen; Sampson, Joshua; Haiman, Christopher A; Li, Dalin; Albanes, Demetrius; Novak, Anne J; Holly, Elizabeth A; Brown, Elizabeth E; Bracci, Paige M; Lake, Annette; Breeze, Charles; Magnani, Corrado; Weiderpass, Elisabete; Conde, Lucia; Smedby, Karin E; Brooks-Wilson, Angela R; Severson, Richard K; Chanock, Stephen J; Liebow, Mark; Cozen, Wendy; Birmann, Brenda M; Smith, Martyn T; Vajdic, Claire M; Monnereau, Alain; Glaser, Sally; Vermeulen, Roel C H; Gabbas, Attilio; Glenn, Martha; Nieters, Alexandra; Adami, Hans-Olov

doi:10.1038/s41375-022-01711-0

TY  - JOUR
AU  - Berndt, Sonja I
AU  - Vijai, Joseph
AU  - Benavente, Yolanda
AU  - Camp, Nicola J
AU  - Nieters, Alexandra
AU  - Wang, Zhaoming
AU  - Smedby, Karin E
AU  - Kleinstern, Geffen
AU  - Hjalgrim, Henrik
AU  - Besson, Caroline
AU  - Skibola, Christine F
AU  - Morton, Lindsay M
AU  - Brooks-Wilson, Angela R
AU  - Teras, Lauren R
AU  - Breeze, Charles
AU  - Arias, Joshua
AU  - Adami, Hans-Olov
AU  - Albanes, Demetrius
AU  - Anderson, Kenneth C
AU  - Ansell, Stephen M
AU  - Bassig, Bryan
AU  - Becker, Nikolaus
AU  - Bhatti, Parveen
AU  - Birmann, Brenda M
AU  - Boffetta, Paolo
AU  - Bracci, Paige M
AU  - Brennan, Paul
AU  - Brown, Elizabeth E
AU  - Burdett, Laurie
AU  - Cannon-Albright, Lisa A
AU  - Chang, Ellen T
AU  - Chiu, Brian C H
AU  - Chung, Charles C
AU  - Clavel, Jacqueline
AU  - Cocco, Pierluigi
AU  - Colditz, Graham
AU  - Conde, Lucia
AU  - Conti, David V
AU  - Cox, David G
AU  - Curtin, Karen
AU  - Casabonne, Delphine
AU  - De Vivo, Immaculata
AU  - Diver, W Ryan
AU  - Dogan, Ahmet
AU  - Edlund, Christopher K
AU  - Foretova, Lenka
AU  - Fraumeni, Joseph F
AU  - Gabbas, Attilio
AU  - Ghesquières, Hervé
AU  - Giles, Graham G
AU  - Glaser, Sally
AU  - Glenn, Martha
AU  - Glimelius, Bengt
AU  - Gu, Jian
AU  - Habermann, Thomas M
AU  - Haiman, Christopher A
AU  - Haioun, Corinne
AU  - Hofmann, Jonathan N
AU  - Holford, Theodore R
AU  - Holly, Elizabeth A
AU  - Hutchinson, Amy
AU  - Izhar, Aalin
AU  - Jackson, Rebecca D
AU  - Jarrett, Ruth F
AU  - Kaaks, Rudolph
AU  - Kane, Eleanor
AU  - Kolonel, Laurence N
AU  - Kong, Yinfei
AU  - Kraft, Peter
AU  - Kricker, Anne
AU  - Lake, Annette
AU  - Lan, Qing
AU  - Lawrence, Charles
AU  - Li, Dalin
AU  - Liebow, Mark
AU  - Link, Brian K
AU  - Magnani, Corrado
AU  - Maynadie, Marc
AU  - McKay, James
AU  - Melbye, Mads
AU  - Miligi, Lucia
AU  - Milne, Roger L
AU  - Molina, Thierry J
AU  - Monnereau, Alain
AU  - Montalvan, Rebecca
AU  - North, Kari E
AU  - Novak, Anne J
AU  - Onel, Kenan
AU  - Purdue, Mark P
AU  - Rand, Kristin A
AU  - Riboli, Elio
AU  - Riby, Jacques
AU  - Roman, Eve
AU  - Salles, Gilles
AU  - Sborov, Douglas W
AU  - Severson, Richard K
AU  - Shanafelt, Tait D
AU  - Smith, Martyn T
AU  - Smith, Alexandra
AU  - Song, Kevin W
AU  - Song, Lei
AU  - Southey, Melissa C
AU  - Spinelli, John J
AU  - Staines, Anthony
AU  - Stephens, Deborah
AU  - Sutherland, Heather J
AU  - Tkachuk, Kaitlyn
AU  - Thompson, Carrie A
AU  - Tilly, Hervé
AU  - Tinker, Lesley F
AU  - Travis, Ruth C
AU  - Turner, Jenny
AU  - Vachon, Celine M
AU  - Vajdic, Claire M
AU  - Van Den Berg, Anke
AU  - Van Den Berg, David J
AU  - Vermeulen, Roel C H
AU  - Vineis, Paolo
AU  - Wang, Sophia S
AU  - Weiderpass, Elisabete
AU  - Weiner, George J
AU  - Weinstein, Stephanie
AU  - Doo, Nicole Wong
AU  - Ye, Yuanqing
AU  - Yeager, Meredith
AU  - Yu, Kai
AU  - Zeleniuch-Jacquotte, Anne
AU  - Zhang, Yawei
AU  - Zheng, Tongzhang
AU  - Ziv, Elad
AU  - Sampson, Joshua
AU  - Chatterjee, Nilanjan
AU  - Offit, Kenneth
AU  - Cozen, Wendy
AU  - Wu, Xifeng
AU  - Cerhan, James R
AU  - Chanock, Stephen J
AU  - Slager, Susan L
AU  - Rothman, Nathaniel
TI  - Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes.
JO  - Leukemia
VL  - 36
IS  - 12
SN  - 0887-6924
CY  - London
PB  - Springer Nature
M1  - DKFZ-2022-02510
SP  - 2835-2844
PY  - 2022
N1  - 2022 Dec;36(12):2835-2844
AB  - Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent of mutual heritability among NHL subtypes and discover novel loci shared among subtypes, we analyzed data from eight genome-wide association studies within the InterLymph Consortium, including 10,629 cases and 9505 controls. We utilized Association analysis based on SubSETs (ASSET) to discover loci for subsets of NHL subtypes and evaluated shared heritability across the genome using Genome-wide Complex Trait Analysis (GCTA) and polygenic risk scores. We discovered 17 genome-wide significant loci (P < 5 × 10-8) for subsets of NHL subtypes, including a novel locus at 10q23.33 (HHEX) (P = 3.27 × 10-9). Most subset associations were driven primarily by only one subtype. Genome-wide genetic correlations between pairs of subtypes varied broadly from 0.20 to 0.86, suggesting substantial heterogeneity in the extent of shared heritability among subtypes. Polygenic risk score analyses of established loci for different lymphoid malignancies identified strong associations with some NHL subtypes (P < 5 × 10-8), but weak or null associations with others. Although our analyses suggest partially shared heritability and biological pathways, they reveal substantial heterogeneity among NHL subtypes with each having its own distinct germline genetic architecture.
LB  - PUB:(DE-HGF)16
C6  - pmid:36273105
DO  - DOI:10.1038/s41375-022-01711-0
UR  - https://inrepo02.dkfz.de/record/182236
ER  -

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