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@ARTICLE{Berndt:182236,
      author       = {S. I. Berndt and J. Vijai and Y. Benavente and N. J. Camp
                      and A. Nieters and Z. Wang and K. E. Smedby and G.
                      Kleinstern and H. Hjalgrim and C. Besson and C. F. Skibola
                      and L. M. Morton and A. R. Brooks-Wilson and L. R. Teras and
                      C. Breeze and J. Arias and H.-O. Adami and D. Albanes and K.
                      C. Anderson and S. M. Ansell and B. Bassig and N. Becker$^*$
                      and P. Bhatti and B. M. Birmann and P. Boffetta and P. M.
                      Bracci and P. Brennan and E. E. Brown and L. Burdett and L.
                      A. Cannon-Albright and E. T. Chang and B. C. H. Chiu and C.
                      C. Chung and J. Clavel and P. Cocco and G. Colditz and L.
                      Conde and D. V. Conti and D. G. Cox and K. Curtin and D.
                      Casabonne and I. De Vivo and W. R. Diver and A. Dogan and C.
                      K. Edlund and L. Foretova and J. F. Fraumeni and A. Gabbas
                      and H. Ghesquières and G. G. Giles and S. Glaser and M.
                      Glenn and B. Glimelius and J. Gu and T. M. Habermann and C.
                      A. Haiman and C. Haioun and J. N. Hofmann and T. R. Holford
                      and E. A. Holly and A. Hutchinson and A. Izhar and R. D.
                      Jackson and R. F. Jarrett and R. Kaaks and E. Kane and L. N.
                      Kolonel and Y. Kong and P. Kraft and A. Kricker and A. Lake
                      and Q. Lan and C. Lawrence and D. Li and M. Liebow and B. K.
                      Link and C. Magnani and M. Maynadie and J. McKay and M.
                      Melbye and L. Miligi and R. L. Milne and T. J. Molina and A.
                      Monnereau and R. Montalvan and K. E. North and A. J. Novak
                      and K. Onel and M. P. Purdue and K. A. Rand and E. Riboli
                      and J. Riby and E. Roman and G. Salles and D. W. Sborov and
                      R. K. Severson and T. D. Shanafelt and M. T. Smith and A.
                      Smith and K. W. Song and L. Song and M. C. Southey and J. J.
                      Spinelli and A. Staines and D. Stephens and H. J. Sutherland
                      and K. Tkachuk and C. A. Thompson and H. Tilly and L. F.
                      Tinker and R. C. Travis and J. Turner and C. M. Vachon and
                      C. M. Vajdic and A. Van Den Berg and D. J. Van Den Berg and
                      R. C. H. Vermeulen and P. Vineis and S. S. Wang and E.
                      Weiderpass and G. J. Weiner and S. Weinstein and N. W. Doo
                      and Y. Ye and M. Yeager and K. Yu and A. Zeleniuch-Jacquotte
                      and Y. Zhang and T. Zheng and E. Ziv and J. Sampson and N.
                      Chatterjee and K. Offit and W. Cozen and X. Wu and J. R.
                      Cerhan and S. J. Chanock and S. L. Slager and N. Rothman},
      title        = {{D}istinct germline genetic susceptibility profiles
                      identified for common non-{H}odgkin lymphoma subtypes.},
      journal      = {Leukemia},
      volume       = {36},
      number       = {12},
      issn         = {0887-6924},
      address      = {London},
      publisher    = {Springer Nature},
      reportid     = {DKFZ-2022-02510},
      pages        = {2835-2844},
      year         = {2022},
      note         = {2022 Dec;36(12):2835-2844},
      abstract     = {Lymphoma risk is elevated for relatives with common
                      non-Hodgkin lymphoma (NHL) subtypes, suggesting shared
                      genetic susceptibility across subtypes. To evaluate the
                      extent of mutual heritability among NHL subtypes and
                      discover novel loci shared among subtypes, we analyzed data
                      from eight genome-wide association studies within the
                      InterLymph Consortium, including 10,629 cases and 9505
                      controls. We utilized Association analysis based on SubSETs
                      (ASSET) to discover loci for subsets of NHL subtypes and
                      evaluated shared heritability across the genome using
                      Genome-wide Complex Trait Analysis (GCTA) and polygenic risk
                      scores. We discovered 17 genome-wide significant loci (P < 5
                      × 10-8) for subsets of NHL subtypes, including a novel
                      locus at 10q23.33 (HHEX) (P = 3.27 × 10-9). Most subset
                      associations were driven primarily by only one subtype.
                      Genome-wide genetic correlations between pairs of subtypes
                      varied broadly from 0.20 to 0.86, suggesting substantial
                      heterogeneity in the extent of shared heritability among
                      subtypes. Polygenic risk score analyses of established loci
                      for different lymphoid malignancies identified strong
                      associations with some NHL subtypes (P < 5 × 10-8), but
                      weak or null associations with others. Although our analyses
                      suggest partially shared heritability and biological
                      pathways, they reveal substantial heterogeneity among NHL
                      subtypes with each having its own distinct germline genetic
                      architecture.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36273105},
      doi          = {10.1038/s41375-022-01711-0},
      url          = {https://inrepo02.dkfz.de/record/182236},
}