%0 Journal Article
%A Roesch, Johannes
%A Oertel, Michael
%A Wegen, Simone
%A Trommer, Maike
%A Schleifenbaum, Julia
%A Hering, Dominik
%A Mäurer, Matthias
%A Knippen, Stefan
%A Dobiasch, Sophie
%A Waltenberger, Maria
%A von der Grün, Jens
%A Medenwald, Daniel
%A Süß, Christoph
%A Hoeck, Michael
%A Käsmann, Lukas
%A Fleischmann, Daniel
%A Rühle, Alexander
%A Nicolay, Nils H
%A Fabian, Alexander
%A Löser, Anastassia
%A Heß, Sebastian
%A Tamaskovics, Bálint
%A Vinsensia, Maria
%A Hecht, Markus
%T Dose-escalated re-irradiation improves outcome in locally recurrent head and neck cancer - Results of a large multicenter analysis.
%J Radiotherapy and oncology
%V 181
%@ 0167-8140
%C Amsterdam [u.a.]
%I Elsevier Science
%M DKFZ-2022-02511
%P 109380
%D 2023
%Z  181, 109380
%X To determine efficacy and prognostic parameters of definitive re-irradiation of locoregionally recurrent squamous cell carcinoma of the head and neck (HNSCC).Patients with locoregionally recurrent or second primary HNSCC undergoing re-irradiation with modern radiotherapy technique were eligible for this multicentric retrospective analysis. Main endpoints were overall survival (OS), progression-free survival (PFS) and locoregional control (LC). Univariate analyses were performed using the Kaplan Meier Method (log-rank). For multivariable analysis, Cox regression was used.A total of 253 patients treated between 2009 and 2020 at 16 university hospitals in Germany were included. The median follow up was 27.4 months (range 0.5 - 130). The median OS and PFS were 13.2 (CI: 10.7 - 15.7) months and 7.9 (CI: 6.7 - 9.1) months, respectively, corresponding to two-year OS and PFS rates of 29
%K HNSCC (Other)
%K Re-Radiochemotherapy (Other)
%K Re-irradiation (Other)
%K head and neck cancer (Other)
%K recurrent (Other)
%K reirradiation (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36273736
%R 10.1016/j.radonc.2022.10.007
%U https://inrepo02.dkfz.de/record/182237