TY  - JOUR
AU  - Roesch, Johannes
AU  - Oertel, Michael
AU  - Wegen, Simone
AU  - Trommer, Maike
AU  - Schleifenbaum, Julia
AU  - Hering, Dominik
AU  - Mäurer, Matthias
AU  - Knippen, Stefan
AU  - Dobiasch, Sophie
AU  - Waltenberger, Maria
AU  - von der Grün, Jens
AU  - Medenwald, Daniel
AU  - Süß, Christoph
AU  - Hoeck, Michael
AU  - Käsmann, Lukas
AU  - Fleischmann, Daniel
AU  - Rühle, Alexander
AU  - Nicolay, Nils H
AU  - Fabian, Alexander
AU  - Löser, Anastassia
AU  - Heß, Sebastian
AU  - Tamaskovics, Bálint
AU  - Vinsensia, Maria
AU  - Hecht, Markus
TI  - Dose-escalated re-irradiation improves outcome in locally recurrent head and neck cancer - Results of a large multicenter analysis.
JO  - Radiotherapy and oncology
VL  - 181
SN  - 0167-8140
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2022-02511
SP  - 109380
PY  - 2023
N1  -  181, 109380
AB  - To determine efficacy and prognostic parameters of definitive re-irradiation of locoregionally recurrent squamous cell carcinoma of the head and neck (HNSCC).Patients with locoregionally recurrent or second primary HNSCC undergoing re-irradiation with modern radiotherapy technique were eligible for this multicentric retrospective analysis. Main endpoints were overall survival (OS), progression-free survival (PFS) and locoregional control (LC). Univariate analyses were performed using the Kaplan Meier Method (log-rank). For multivariable analysis, Cox regression was used.A total of 253 patients treated between 2009 and 2020 at 16 university hospitals in Germany were included. The median follow up was 27.4 months (range 0.5 - 130). The median OS and PFS were 13.2 (CI: 10.7 - 15.7) months and 7.9 (CI: 6.7 - 9.1) months, respectively, corresponding to two-year OS and PFS rates of 29
KW  - HNSCC (Other)
KW  - Re-Radiochemotherapy (Other)
KW  - Re-irradiation (Other)
KW  - head and neck cancer (Other)
KW  - recurrent (Other)
KW  - reirradiation (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36273736
DO  - DOI:10.1016/j.radonc.2022.10.007
UR  - https://inrepo02.dkfz.de/record/182237
ER  -