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000182294 1001_ $$aPeduzzi, Giulia$$b0
000182294 245__ $$aCommon variability in oestrogen-related genes and pancreatic ductal adenocarcinoma risk in women
000182294 260__ $$a[London]$$bMacmillan Publishers Limited, part of Springer Nature$$c2022
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000182294 520__ $$aThe incidence of pancreatic ductal adenocarcinoma (PDAC) is different among males and females. This disparity cannot be fully explained by the difference in terms of exposure to known risk factors; therefore, the lower incidence in women could be attributed to sex-specific hormones. A two-phase association study was conducted in 12,387 female subjects (5436 PDAC cases and 6951 controls) to assess the effect on risk of developing PDAC of single nucleotide polymorphisms (SNPs) in 208 genes involved in oestrogen and pregnenolone biosynthesis and oestrogen-mediated signalling. In the discovery phase 14 polymorphisms showed a statistically significant association (P < 0.05). In the replication none of the findings were validated. In addition, a gene-based analysis was performed on the 208 selected genes. Four genes (NR5A2, MED1, NCOA2 and RUNX1) were associated with PDAC risk, but only NR5A2 showed an association (P = 4.08 × 10-5) below the Bonferroni-corrected threshold of statistical significance. In conclusion, despite differences in incidence between males and females, our study did not identify an effect of common polymorphisms in the oestrogen and pregnenolone pathways in relation to PDAC susceptibility. However, we validated the previously reported association between NR5A2 gene variants and PDAC risk.
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000182294 7001_ $$aArchibugi, Livia$$b1
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000182294 7001_ $$aGentiluomo, Manuel$$b3
000182294 7001_ $$aCapurso, Gabriele$$b4
000182294 7001_ $$aMilanetto, Anna Caterina$$b5
000182294 7001_ $$aGazouli, Maria$$b6
000182294 7001_ $$aGoetz, Mara$$b7
000182294 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b8$$udkfz
000182294 7001_ $$aVermeulen, Roel C. H.$$b9
000182294 7001_ $$aTalar-Wojnarowska, Renata$$b10
000182294 7001_ $$aVanella, Giuseppe$$b11
000182294 7001_ $$aTavano, Francesca$$b12
000182294 7001_ $$aLucchesi, Maurizio$$b13
000182294 7001_ $$aMohelnikova-Duchonova, Beatrice$$b14
000182294 7001_ $$0P:(DE-He78)c392ec8a090dcfbe801f135a6212caf9$$aChen, Xuechen$$b15$$udkfz
000182294 7001_ $$aKiudelis, Vytautas$$b16
000182294 7001_ $$aHegyi, Péter$$b17
000182294 7001_ $$aOliverius, Martin$$b18
000182294 7001_ $$0P:(DE-He78)104fae0755c89365b7ae32238b3f1f52$$aStocker, Hannah$$b19$$udkfz
000182294 7001_ $$aStornello, Caterina$$b20
000182294 7001_ $$aVodickova, Ludmila$$b21
000182294 7001_ $$aSouček, Pavel$$b22
000182294 7001_ $$aNeoptolemos, John P.$$b23
000182294 7001_ $$aTestoni, Sabrina Gloria Giulia$$b24
000182294 7001_ $$aMorelli, Luca$$b25
000182294 7001_ $$aLawlor, Rita T.$$b26
000182294 7001_ $$aBasso, Daniela$$b27
000182294 7001_ $$aIzbicki, Jakob R.$$b28
000182294 7001_ $$aErmini, Stefano$$b29
000182294 7001_ $$aKupcinskas, Juozas$$b30
000182294 7001_ $$aPezzilli, Raffaele$$b31
000182294 7001_ $$aBoggi, Ugo$$b32
000182294 7001_ $$avan Laarhoven, Hanneke W. M.$$b33
000182294 7001_ $$aSzentesi, Andrea$$b34
000182294 7001_ $$aErőss, Bálint$$b35
000182294 7001_ $$aCapretti, Giovanni$$b36
000182294 7001_ $$0P:(DE-He78)c67a12496b8aac150c0eef888d808d46$$aSchöttker, Ben$$b37$$udkfz
000182294 7001_ $$aSkieceviciene, Jurgita$$b38
000182294 7001_ $$aAoki, Mateus Nóbrega$$b39
000182294 7001_ $$avan Eijck, Casper H. J.$$b40
000182294 7001_ $$aCavestro, Giulia Martina$$b41
000182294 7001_ $$0P:(DE-He78)5323704270b6393dcea70186ffd86bca$$aCanzian, Federico$$b42$$eLast author$$udkfz
000182294 7001_ $$aCampa, Daniele$$b43
000182294 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/s41598-022-22973-9$$gVol. 12, no. 1, p. 18100$$n1$$p18100$$tScientific reports$$v12$$x2045-2322$$y2022
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