TY  - JOUR
AU  - Peduzzi, Giulia
AU  - Archibugi, Livia
AU  - Katzke, Verena
AU  - Gentiluomo, Manuel
AU  - Capurso, Gabriele
AU  - Milanetto, Anna Caterina
AU  - Gazouli, Maria
AU  - Goetz, Mara
AU  - Brenner, Hermann
AU  - Vermeulen, Roel C. H.
AU  - Talar-Wojnarowska, Renata
AU  - Vanella, Giuseppe
AU  - Tavano, Francesca
AU  - Lucchesi, Maurizio
AU  - Mohelnikova-Duchonova, Beatrice
AU  - Chen, Xuechen
AU  - Kiudelis, Vytautas
AU  - Hegyi, Péter
AU  - Oliverius, Martin
AU  - Stocker, Hannah
AU  - Stornello, Caterina
AU  - Vodickova, Ludmila
AU  - Souček, Pavel
AU  - Neoptolemos, John P.
AU  - Testoni, Sabrina Gloria Giulia
AU  - Morelli, Luca
AU  - Lawlor, Rita T.
AU  - Basso, Daniela
AU  - Izbicki, Jakob R.
AU  - Ermini, Stefano
AU  - Kupcinskas, Juozas
AU  - Pezzilli, Raffaele
AU  - Boggi, Ugo
AU  - van Laarhoven, Hanneke W. M.
AU  - Szentesi, Andrea
AU  - Erőss, Bálint
AU  - Capretti, Giovanni
AU  - Schöttker, Ben
AU  - Skieceviciene, Jurgita
AU  - Aoki, Mateus Nóbrega
AU  - van Eijck, Casper H. J.
AU  - Cavestro, Giulia Martina
AU  - Canzian, Federico
AU  - Campa, Daniele
TI  - Common variability in oestrogen-related genes and pancreatic ductal adenocarcinoma risk in women
JO  - Scientific reports
VL  - 12
IS  - 1
SN  - 2045-2322
CY  - [London]
PB  - Macmillan Publishers Limited, part of Springer Nature
M1  - DKFZ-2022-02551
SP  - 18100
PY  - 2022
N1  - #LA:C055#
AB  - The incidence of pancreatic ductal adenocarcinoma (PDAC) is different among males and females. This disparity cannot be fully explained by the difference in terms of exposure to known risk factors; therefore, the lower incidence in women could be attributed to sex-specific hormones. A two-phase association study was conducted in 12,387 female subjects (5436 PDAC cases and 6951 controls) to assess the effect on risk of developing PDAC of single nucleotide polymorphisms (SNPs) in 208 genes involved in oestrogen and pregnenolone biosynthesis and oestrogen-mediated signalling. In the discovery phase 14 polymorphisms showed a statistically significant association (P < 0.05). In the replication none of the findings were validated. In addition, a gene-based analysis was performed on the 208 selected genes. Four genes (NR5A2, MED1, NCOA2 and RUNX1) were associated with PDAC risk, but only NR5A2 showed an association (P = 4.08 × 10-5) below the Bonferroni-corrected threshold of statistical significance. In conclusion, despite differences in incidence between males and females, our study did not identify an effect of common polymorphisms in the oestrogen and pregnenolone pathways in relation to PDAC susceptibility. However, we validated the previously reported association between NR5A2 gene variants and PDAC risk.
LB  - PUB:(DE-HGF)16
C6  - pmid:36302831
DO  - DOI:10.1038/s41598-022-22973-9
UR  - https://inrepo02.dkfz.de/record/182294
ER  -