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@ARTICLE{Peduzzi:182294,
      author       = {G. Peduzzi and L. Archibugi and V. Katzke$^*$ and M.
                      Gentiluomo and G. Capurso and A. C. Milanetto and M. Gazouli
                      and M. Goetz and H. Brenner$^*$ and R. C. H. Vermeulen and
                      R. Talar-Wojnarowska and G. Vanella and F. Tavano and M.
                      Lucchesi and B. Mohelnikova-Duchonova and X. Chen$^*$ and V.
                      Kiudelis and P. Hegyi and M. Oliverius and H. Stocker$^*$
                      and C. Stornello and L. Vodickova and P. Souček and J. P.
                      Neoptolemos and S. G. G. Testoni and L. Morelli and R. T.
                      Lawlor and D. Basso and J. R. Izbicki and S. Ermini and J.
                      Kupcinskas and R. Pezzilli and U. Boggi and H. W. M. van
                      Laarhoven and A. Szentesi and B. Erőss and G. Capretti and
                      B. Schöttker$^*$ and J. Skieceviciene and M. N. Aoki and C.
                      H. J. van Eijck and G. M. Cavestro and F. Canzian$^*$ and D.
                      Campa},
      title        = {{C}ommon variability in oestrogen-related genes and
                      pancreatic ductal adenocarcinoma risk in women},
      journal      = {Scientific reports},
      volume       = {12},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DKFZ-2022-02551},
      pages        = {18100},
      year         = {2022},
      note         = {#LA:C055#},
      abstract     = {The incidence of pancreatic ductal adenocarcinoma (PDAC) is
                      different among males and females. This disparity cannot be
                      fully explained by the difference in terms of exposure to
                      known risk factors; therefore, the lower incidence in women
                      could be attributed to sex-specific hormones. A two-phase
                      association study was conducted in 12,387 female subjects
                      (5436 PDAC cases and 6951 controls) to assess the effect on
                      risk of developing PDAC of single nucleotide polymorphisms
                      (SNPs) in 208 genes involved in oestrogen and pregnenolone
                      biosynthesis and oestrogen-mediated signalling. In the
                      discovery phase 14 polymorphisms showed a statistically
                      significant association (P < 0.05). In the replication none
                      of the findings were validated. In addition, a gene-based
                      analysis was performed on the 208 selected genes. Four genes
                      (NR5A2, MED1, NCOA2 and RUNX1) were associated with PDAC
                      risk, but only NR5A2 showed an association (P = 4.08 ×
                      10-5) below the Bonferroni-corrected threshold of
                      statistical significance. In conclusion, despite differences
                      in incidence between males and females, our study did not
                      identify an effect of common polymorphisms in the oestrogen
                      and pregnenolone pathways in relation to PDAC
                      susceptibility. However, we validated the previously
                      reported association between NR5A2 gene variants and PDAC
                      risk.},
      cin          = {C020 / C070 / C120 / C055 / HD01},
      ddc          = {600},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)C120-20160331 / I:(DE-He78)C055-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36302831},
      doi          = {10.1038/s41598-022-22973-9},
      url          = {https://inrepo02.dkfz.de/record/182294},
}