TY  - JOUR
AU  - Kirste, Simon
AU  - Rühle, Alexander
AU  - Zschiedrich, Stefan
AU  - Schultze-Seemann, Wolfgang
AU  - Jilg, Cordula A
AU  - Neumann-Haefelin, Elke
AU  - Lo, Simon S
AU  - Grosu, Anca-Ligia
AU  - Kim, Emily
TI  - Stereotactic Body Radiotherapy for Renal Cell Carcinoma in Patients with Von Hippel-Lindau Disease-Results of a Prospective Trial.
JO  - Cancers
VL  - 14
IS  - 20
SN  - 2072-6694
CY  - Basel
PB  - MDPI
M1  - DKFZ-2022-02565
SP  - 5069
PY  - 2022
AB  - Von Hippel-Lindau disease (VHL) is a hereditary disorder associated with malignant tumors including clear cell renal cell carcinoma (ccRCC). Partial nephrectomy is complicated by multilocular tumor occurrence and a high recurrence rate. The aim of this study was to evaluate the potential of stereotactic body radiotherapy (SBRT) as an alternative treatment approach in VHL patients with multiple ccRCC. Patients with VHL and a diagnosis of ccRCC were enrolled. SBRT was conducted using five fractions of 10 Gy or eight fractions of 7.5 Gy. The primary endpoint was local control (LC). Secondary endpoints included alteration of renal function and adverse events. Seven patients with a total of eight treated lesions were enrolled. Median age was 44 years. Five patients exhibited multiple bilateral kidney cysts in addition to ccRCC. Three patients underwent at least one partial nephrectomy in the past. After a median follow-up of 43 months, 2-year LC was 100
KW  - SABR (Other)
KW  - SBRT (Other)
KW  - renal cell carcinoma (Other)
KW  - stereotactic ablative radiotherapy (Other)
KW  - stereotactic body radiotherapy (Other)
KW  - von Hippel–Lindau disease (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36291853
DO  - DOI:10.3390/cancers14205069
UR  - https://inrepo02.dkfz.de/record/182308
ER  -