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@ARTICLE{Kirste:182308,
      author       = {S. Kirste$^*$ and A. Rühle$^*$ and S. Zschiedrich and W.
                      Schultze-Seemann and C. A. Jilg and E. Neumann-Haefelin and
                      S. S. Lo and A.-L. Grosu$^*$ and E. Kim$^*$},
      title        = {{S}tereotactic {B}ody {R}adiotherapy for {R}enal {C}ell
                      {C}arcinoma in {P}atients with {V}on {H}ippel-{L}indau
                      {D}isease-{R}esults of a {P}rospective {T}rial.},
      journal      = {Cancers},
      volume       = {14},
      number       = {20},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2022-02565},
      pages        = {5069},
      year         = {2022},
      abstract     = {Von Hippel-Lindau disease (VHL) is a hereditary disorder
                      associated with malignant tumors including clear cell renal
                      cell carcinoma (ccRCC). Partial nephrectomy is complicated
                      by multilocular tumor occurrence and a high recurrence rate.
                      The aim of this study was to evaluate the potential of
                      stereotactic body radiotherapy (SBRT) as an alternative
                      treatment approach in VHL patients with multiple ccRCC.
                      Patients with VHL and a diagnosis of ccRCC were enrolled.
                      SBRT was conducted using five fractions of 10 Gy or eight
                      fractions of 7.5 Gy. The primary endpoint was local control
                      (LC). Secondary endpoints included alteration of renal
                      function and adverse events. Seven patients with a total of
                      eight treated lesions were enrolled. Median age was 44
                      years. Five patients exhibited multiple bilateral kidney
                      cysts in addition to ccRCC. Three patients underwent at
                      least one partial nephrectomy in the past. After a median
                      follow-up of 43 months, 2-year LC was $100\%,$ while 2-year
                      CSS, 2-year PFS and 2-year OS was $100\%,$ $85.7\%$ and
                      $85.7\%,$ respectively. SBRT was very well tolerated with no
                      acute or chronic toxicities grade ≥ 2. Mean estimated
                      glomerular filtration rate (eGFR) at baseline was 83.7 ±
                      13.0 mL/min/1.73 m2, which decreased to 76.6 ± 8.0
                      mL/min/1.73 m2 after 1 year. Although the sample size was
                      small, SBRT resulted in an excellent LC rate and was very
                      well tolerated with preservation of kidney function in
                      patients with multiple renal lesions and cysts.},
      keywords     = {SABR (Other) / SBRT (Other) / renal cell carcinoma (Other)
                      / stereotactic ablative radiotherapy (Other) / stereotactic
                      body radiotherapy (Other) / von Hippel–Lindau disease
                      (Other)},
      cin          = {FR01 / E055},
      ddc          = {610},
      cid          = {I:(DE-He78)FR01-20160331 / I:(DE-He78)E055-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:36291853},
      doi          = {10.3390/cancers14205069},
      url          = {https://inrepo02.dkfz.de/record/182308},
}