%0 Journal Article
%A Wu, Wendy Yi-Ying
%A Haider, Zahra
%A Feng, Xiaoshuang
%A Heath, Alicia K
%A Tjønneland, Anne
%A Agudo, Antonio
%A Masala, Giovanna
%A Robbins, Hilary A
%A Huerta, María-José
%A Guevara, Marcela
%A Schulze, Matthias B
%A Rodriguez-Barranco, Miguel
%A Vineis, Paolo
%A Tumino, Rosario
%A Kaaks, Rudolf
%A Turzanski-Fortner, Renée
%A Sieri, Sabina
%A Panico, Salvatore
%A Nøst, Therese Haugdahl
%A Sandanger, Torkjel M
%A Braaten, Tonje
%A Johansson, Mattias
%A Melin, Beatrice
%A Johansson, Mikael
%T Assessment of the EarlyCDT-Lung test as an early biomarker of lung cancer in ever-smokers - A retrospective nested case-control study in two prospective cohorts.
%J International journal of cancer
%V 152
%N 9
%@ 0020-7136
%C Bognor Regis
%I Wiley-Liss
%M DKFZ-2022-02584
%P 2002-2010
%D 2023
%Z 2023 May 1;152(9):2002-2010
%X The EarlyCDT-Lung test is a blood-based autoantibody assay intended to identify high-risk individuals for low-dose computed tomography lung cancer screening. However, there is a paucity of evidence on the performance of the EarlyCDT-Lung test in ever-smokers. We conducted a nested case-control study within two prospective cohorts to evaluate the risk-discriminatory performance of the EarlyCDT-Lung test using pre-diagnostic blood samples from 154 future lung cancer cases and 154 matched controls. Cases were selected from those who had ever smoked and had a pre-diagnostic blood samples less than 3 years prior to diagnosis. Conditional logistic regression was used to estimate the association between EarlyCDT-Lung test results and lung cancer risk. Sensitivity and specificity of the EarlyCDT-Lung test were calculated in all subjects and subgroups based on age, smoking history, lung cancer stage, sample collection time before diagnosis and year of sample collection. The overall lung cancer odds ratios were 0.89 (95
%K EarlyCDT-Lung test (Other)
%K biomarkers (Other)
%K lung cancer (Other)
%K prediagnostic samples (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36305647
%R 10.1002/ijc.34340
%U https://inrepo02.dkfz.de/record/182341