000182341 001__ 182341
000182341 005__ 20240229145716.0
000182341 0247_ $$2doi$$a10.1002/ijc.34340
000182341 0247_ $$2pmid$$apmid:36305647
000182341 0247_ $$2ISSN$$a0020-7136
000182341 0247_ $$2ISSN$$a1097-0215
000182341 0247_ $$2altmetric$$aaltmetric:137818439
000182341 037__ $$aDKFZ-2022-02584
000182341 041__ $$aEnglish
000182341 082__ $$a610
000182341 1001_ $$00000-0002-6169-5155$$aWu, Wendy Yi-Ying$$b0
000182341 245__ $$aAssessment of the EarlyCDT-Lung test as an early biomarker of lung cancer in ever-smokers - A retrospective nested case-control study in two prospective cohorts.
000182341 260__ $$aBognor Regis$$bWiley-Liss$$c2023
000182341 3367_ $$2DRIVER$$aarticle
000182341 3367_ $$2DataCite$$aOutput Types/Journal article
000182341 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1678877447_29495
000182341 3367_ $$2BibTeX$$aARTICLE
000182341 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000182341 3367_ $$00$$2EndNote$$aJournal Article
000182341 500__ $$a2023 May 1;152(9):2002-2010
000182341 520__ $$aThe EarlyCDT-Lung test is a blood-based autoantibody assay intended to identify high-risk individuals for low-dose computed tomography lung cancer screening. However, there is a paucity of evidence on the performance of the EarlyCDT-Lung test in ever-smokers. We conducted a nested case-control study within two prospective cohorts to evaluate the risk-discriminatory performance of the EarlyCDT-Lung test using pre-diagnostic blood samples from 154 future lung cancer cases and 154 matched controls. Cases were selected from those who had ever smoked and had a pre-diagnostic blood samples less than 3 years prior to diagnosis. Conditional logistic regression was used to estimate the association between EarlyCDT-Lung test results and lung cancer risk. Sensitivity and specificity of the EarlyCDT-Lung test were calculated in all subjects and subgroups based on age, smoking history, lung cancer stage, sample collection time before diagnosis and year of sample collection. The overall lung cancer odds ratios were 0.89 (95% CI, 0.34-2.30) for a moderate risk EarlyCDT-Lung test result and 1.09 (95% CI, 0.48-2.47) for a high-risk test result compared to no significant test result. The overall sensitivity was 8.4% (95% CI, 4.6-14) and overall specificity was 92% (95% CI, 87-96) when considering a high-risk result as positive. Stratified analysis indicated higher sensitivity (17%, 95% CI, 7.2-32.1) in subjects with blood drawn up to 1 year prior to diagnosis. In conclusion, our study does not support a role of the EarlyCDT-Lung test in identifying the high-risk subjects in ever-smokers for lung cancer screening in the EPIC and NSHDS cohorts.
000182341 536__ $$0G:(DE-HGF)POF4-313$$a313 - Krebsrisikofaktoren und Prävention (POF4-313)$$cPOF4-313$$fPOF IV$$x0
000182341 588__ $$aDataset connected to CrossRef, PubMed, , Journals: inrepo02.dkfz.de
000182341 650_7 $$2Other$$aEarlyCDT-Lung test
000182341 650_7 $$2Other$$abiomarkers
000182341 650_7 $$2Other$$alung cancer
000182341 650_7 $$2Other$$aprediagnostic samples
000182341 7001_ $$aHaider, Zahra$$b1
000182341 7001_ $$aFeng, Xiaoshuang$$b2
000182341 7001_ $$00000-0001-6517-1300$$aHeath, Alicia K$$b3
000182341 7001_ $$aTjønneland, Anne$$b4
000182341 7001_ $$aAgudo, Antonio$$b5
000182341 7001_ $$aMasala, Giovanna$$b6
000182341 7001_ $$00000-0001-6041-6866$$aRobbins, Hilary A$$b7
000182341 7001_ $$aHuerta, María-José$$b8
000182341 7001_ $$aGuevara, Marcela$$b9
000182341 7001_ $$aSchulze, Matthias B$$b10
000182341 7001_ $$aRodriguez-Barranco, Miguel$$b11
000182341 7001_ $$aVineis, Paolo$$b12
000182341 7001_ $$aTumino, Rosario$$b13
000182341 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b14$$udkfz
000182341 7001_ $$0P:(DE-He78)74a6af8347ec5cbd4b77e562e10ca1f2$$aTurzanski-Fortner, Renée$$b15$$udkfz
000182341 7001_ $$00000-0001-5201-172X$$aSieri, Sabina$$b16
000182341 7001_ $$aPanico, Salvatore$$b17
000182341 7001_ $$aNøst, Therese Haugdahl$$b18
000182341 7001_ $$aSandanger, Torkjel M$$b19
000182341 7001_ $$aBraaten, Tonje$$b20
000182341 7001_ $$aJohansson, Mattias$$b21
000182341 7001_ $$aMelin, Beatrice$$b22
000182341 7001_ $$aJohansson, Mikael$$b23
000182341 773__ $$0PERI:(DE-600)1474822-8$$a10.1002/ijc.34340$$gp. ijc.34340$$n9$$p2002-2010$$tInternational journal of cancer$$v152$$x0020-7136$$y2023
000182341 909CO $$ooai:inrepo02.dkfz.de:182341$$pVDB
000182341 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aDeutsches Krebsforschungszentrum$$b14$$kDKFZ
000182341 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)74a6af8347ec5cbd4b77e562e10ca1f2$$aDeutsches Krebsforschungszentrum$$b15$$kDKFZ
000182341 9131_ $$0G:(DE-HGF)POF4-313$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vKrebsrisikofaktoren und Prävention$$x0
000182341 9141_ $$y2022
000182341 915__ $$0StatID:(DE-HGF)3001$$2StatID$$aDEAL Wiley$$d2021-02-04$$wger
000182341 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2021-02-04
000182341 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2021-02-04
000182341 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2021-02-04
000182341 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2023-10-21$$wger
000182341 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-10-21
000182341 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-10-21
000182341 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-10-21
000182341 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-10-21
000182341 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-10-21
000182341 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2023-10-21
000182341 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bINT J CANCER : 2022$$d2023-10-21
000182341 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bINT J CANCER : 2022$$d2023-10-21
000182341 9201_ $$0I:(DE-He78)C020-20160331$$kC020$$lC020 Epidemiologie von Krebs$$x0
000182341 980__ $$ajournal
000182341 980__ $$aVDB
000182341 980__ $$aI:(DE-He78)C020-20160331
000182341 980__ $$aUNRESTRICTED