TY  - JOUR
AU  - Wu, Wendy Yi-Ying
AU  - Haider, Zahra
AU  - Feng, Xiaoshuang
AU  - Heath, Alicia K
AU  - Tjønneland, Anne
AU  - Agudo, Antonio
AU  - Masala, Giovanna
AU  - Robbins, Hilary A
AU  - Huerta, María-José
AU  - Guevara, Marcela
AU  - Schulze, Matthias B
AU  - Rodriguez-Barranco, Miguel
AU  - Vineis, Paolo
AU  - Tumino, Rosario
AU  - Kaaks, Rudolf
AU  - Turzanski-Fortner, Renée
AU  - Sieri, Sabina
AU  - Panico, Salvatore
AU  - Nøst, Therese Haugdahl
AU  - Sandanger, Torkjel M
AU  - Braaten, Tonje
AU  - Johansson, Mattias
AU  - Melin, Beatrice
AU  - Johansson, Mikael
TI  - Assessment of the EarlyCDT-Lung test as an early biomarker of lung cancer in ever-smokers - A retrospective nested case-control study in two prospective cohorts.
JO  - International journal of cancer
VL  - 152
IS  - 9
SN  - 0020-7136
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2022-02584
SP  - 2002-2010
PY  - 2023
N1  - 2023 May 1;152(9):2002-2010
AB  - The EarlyCDT-Lung test is a blood-based autoantibody assay intended to identify high-risk individuals for low-dose computed tomography lung cancer screening. However, there is a paucity of evidence on the performance of the EarlyCDT-Lung test in ever-smokers. We conducted a nested case-control study within two prospective cohorts to evaluate the risk-discriminatory performance of the EarlyCDT-Lung test using pre-diagnostic blood samples from 154 future lung cancer cases and 154 matched controls. Cases were selected from those who had ever smoked and had a pre-diagnostic blood samples less than 3 years prior to diagnosis. Conditional logistic regression was used to estimate the association between EarlyCDT-Lung test results and lung cancer risk. Sensitivity and specificity of the EarlyCDT-Lung test were calculated in all subjects and subgroups based on age, smoking history, lung cancer stage, sample collection time before diagnosis and year of sample collection. The overall lung cancer odds ratios were 0.89 (95
KW  - EarlyCDT-Lung test (Other)
KW  - biomarkers (Other)
KW  - lung cancer (Other)
KW  - prediagnostic samples (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:36305647
DO  - DOI:10.1002/ijc.34340
UR  - https://inrepo02.dkfz.de/record/182341
ER  -