%0 Journal Article
%A Gaziano, Liam
%A Sun, Luanluan
%A Arnold, Matthew
%A Bell, Steven
%A Cho, Kelly
%A Kaptoge, Stephen K.
%A Song, Rebecca J.
%A Burgess, Stephen
%A Posner, Daniel C.
%A Mosconi, Katja
%A Robinson-Cohen, Cassianne
%A Mason, Amy
%A Bolton, Thomas R.
%A Tao, Ran
%A Allara, Elias
%A Schubert, Petra
%A Chen, Lingyan
%A Staley, James R.
%A Staplin, Natalie
%A Altay, Servet
%A Amiano, Pilar
%A Arndt, Volker
%A Ärnlöv, Johan
%A Barr, Elizabeth L. M.
%A Björkelund, Cecilia
%A Boer, Jolanda M. A.
%A Brenner, Hermann
%A Casiglia, Edoardo
%A Chiodini, Paolo
%A Cooper, Jackie A.
%A Coresh, Josef
%A Cushman, Mary
%A Dankner, Rachel
%A Davidson, Karina W.
%A de Jongh, Renate T.
%A Donfrancesco, Chiara
%A Engström, Gunnar
%A Freisling, Heinz
%A de la Cámara, Agustin Gómez
%A Gudnason, Vilmundur
%A Hankey, Graeme J.
%A Hansson, Per-Olof
%A Heath, Alicia K.
%A Hoorn, Ewout J.
%A Imano, Hironori
%A Jassal, Simerjot K.
%A Kaaks, Rudolf
%A Katzke, Verena
%A Kauhanen, Jussi
%A Kiechl, Stefan
%A Koenig, Wolfgang
%A Kronmal, Richard A.
%A Kyrø, Cecilie
%A Lawlor, Deborah A.
%A Ljungberg, Börje
%A MacDonald, Conor
%A Masala, Giovanna
%A Meisinger, Christa
%A Melander, Olle
%A Moreno Iribas, Conchi
%A Ninomiya, Toshiharu
%A Nitsch, Dorothea
%A Nordestgaard, Børge G.
%A Onland-Moret, Charlotte
%A Palmieri, Luigi
%A Petrova, Dafina
%A Garcia, Jose Ramón Quirós
%A Rosengren, Annika
%A Sacerdote, Carlotta
%A Sakurai, Masaru
%A Santiuste, Carmen
%A Schulze, Matthias B.
%A Sieri, Sabina
%A Sundström, Johan
%A Tikhonoff, Valérie
%A Tjønneland, Anne
%A Tong, Tammy
%A Tumino, Rosario
%A Tzoulaki, Ioanna
%A van der Schouw, Yvonne T.
%A Monique Verschuren, W. M.
%A Völzke, Henry
%A Wallace, Robert B.
%A Goya Wannamethee, S.
%A Weiderpass, Elisabete
%A Willeit, Peter
%A Woodward, Mark
%A Yamagishi, Kazumasa
%A Zamora-Ros, Raul
%A Akwo, Elvis A.
%A Pyarajan, Saiju
%A Gagnon, David R.
%A Tsao, Philip S.
%A Muralidhar, Sumitra
%A Edwards, Todd L.
%A Damrauer, Scott M.
%A Joseph, Jacob
%A Pennells, Lisa
%A Wilson, Peter W. F.
%A Harrison, Seamus
%A Gaziano, Thomas A.
%A Inouye, Michael
%A Baigent, Colin
%A Casas, Juan P.
%A Langenberg, Claudia
%A Wareham, Nick
%A Riboli, Elio
%A Michael Gaziano, J.
%A Danesh, John
%A Hung, Adriana M.
%A Butterworth, Adam S.
%A Wood, Angela M.
%A Di Angelantonio, Emanuele
%A Koettgen, Anna
%A Shaw, Jonathan
%A Atkins, Robert
%A Zimmet, Paul
%A Whincup, Peter
%A Willeit, Johann
%A Leitner, Christoph
%A Schnohr, Peter
%A Afzal, Shoaib
%A Pablos, David Lora
%A Arriscado, Cristina Martin
%A Ferreiro, Carmen Romero
%A Stocker, Hannah
%A Schöttker, Ben
%A Holleczek, Bernd
%A Chetrit, Angela
%A Welin, Lennart
%A Svärdsudd, Kurt
%A Welin, Lennart
%A Svärdsudd, Kurt
%A Lissner, Lauren
%A Hange, Dominique
%A Mehlig, Kirsten
%A Nagel, Dorothea
%A Norman, Paul E.
%A Almeida, Osvaldo
%A Flicker, Leon
%A Hata, Jun
%A Honda, Takanori
%A Furuta, Yoshihiko
%A Iso, Hiroyasu
%A Kitamura, Akihiko
%A Muraki, Isao
%A Salonen, Jukka T.
%A Tuomainen, Tomi-Pekka
%A van Zutphen, E. M.
%A van Schoor, N. M.
%A Lo Noce, Cinzia
%A Lappas, Georg
%A Nilsson, Peter M.
%A Hedblad, Bo
%A Shaffer, Jonathan
%A Schwartz, Joseph
%A Shimbo, Daichi
%A Sato, Shinichi
%A Iso, Hiroyasu
%A Hayama-Terada, Mina
%A Aspelund, Thor
%A Thorsson, Bolli
%A Sigurdsson, Gunnar
%A Chaker, Layal
%A Ikram, Kamran M.
%A Kavousi, Maryam
%A Tunstall-Pedoe, Hugh
%A Can, Günay
%A Yüksel, Hüsniye
%A Özkan, Uğur
%A Nakagawa, Hideaki
%A Morikawa, Yuko
%A Ishizaki, Masao
%A Feskens, Edith
%A Geleijnse, Johanna M
%A Kromhout, Daan
%T Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses
%J Circulation
%V 146
%N 20
%@ 0009-7322
%C [S.l.]
%I Ovid
%M DKFZ-2022-02595
%P 1507-1517
%D 2022
%Z 2022 Nov 15;146(20):1507-1517
%X Background: End-stage renal disease is associated with a high risk of cardiovascular events. It is unknown, however, whether mild-to-moderate kidney dysfunction is causally related to coronary heart disease (CHD) and stroke.Methods: Observational analyses were conducted using individual-level data from 4 population data sources (Emerging Risk Factors Collaboration, EPIC-CVD [European Prospective Investigation into Cancer and Nutrition-Cardiovascular Disease Study], Million Veteran Program, and UK Biobank), comprising 648 135 participants with no history of cardiovascular disease or diabetes at baseline, yielding 42 858 and 15 693 incident CHD and stroke events, respectively, during 6.8 million person-years of follow-up. Using a genetic risk score of 218 variants for estimated glomerular filtration rate (eGFR), we conducted Mendelian randomization analyses involving 413 718 participants (25 917 CHD and 8622 strokes) in EPIC-CVD, Million Veteran Program, and UK Biobank.Results: There were U-shaped observational associations of creatinine-based eGFR with CHD and stroke, with higher risk in participants with eGFR values <60 or >105 mL·min-1·1.73 m-2, compared with those with eGFR between 60 and 105 mL·min-1·1.73 m-2. Mendelian randomization analyses for CHD showed an association among participants with eGFR <60 mL·min-1·1.73 m-2, with a 14
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:36314129
%R 10.1161/CIRCULATIONAHA.122.060700
%U https://inrepo02.dkfz.de/record/182352